Compatibility of Vancomycin and Oxacillin During Simulated Y-Site Delivery.

Background: Vancomycin and oxacillin may be used together as empiric coverage in patients with proven or suspected Staphylococcus aureus infections. Though vancomycin hydrochloride 20 mg/mL and oxacillin sodium 160 mg/mL are reported to be compatible via Y-site delivery, Y-site compatibility of commonly used concentrations, vancomycin 10 mg/mL and oxacillin 20 mg/mL, has not yet been reported.

Objective: To determine the Y-site compatibility of vancomycin 10 mg/mL and oxacillin 20 mg/mL.