Long-Term Exposure to Nitrogen Dioxide and Ozone and Respiratory Health in Children.

Rationale: Further evaluation of the impact of long-term exposure to the gaseous air pollutants nitrogen dioxide (NO) and ozone (O) on child lung function, and of NO or O on eosinophilic airway inflammation, is needed.

Objective: To determine whether NO and O are associated with lung function and FeNO in children.

Methods: We measured lung function (FEV1 and FVC) at mid-childhood (mean age 7.

Comparison of multiplexed protein analysis platforms for the detection of biomarkers in the nasal epithelial lining fluid of healthy subjects.

Background: Multiplexed protein analysis platforms are a novel and efficient way to characterize biomarkers in a variety of biological samples. Few studies have compared protein quantitation and reproducibility of results across platforms. We utilize a novel nasosorption technique to collect nasal epithelial lining fluid (NELF) from healthy subjects, and compare the detection of proteins in NELF across three commonly used platforms.

Personal air pollution exposure and metals in the nasal epithelial lining fluid of COPD patients.

Sampling of the nasal epithelial lining fluid is a potential method to assess exposure to air pollution within the respiratory tract among high risk populations. We investigated associations of short- and long-term particulate matter exposure (PM) and pollution-related metals in the nasal fluid of people with chronic obstructive pulmonary disease (COPD). This study included 20 participants with moderate-to-severe COPD from a larger study who measured long-term personal exposure to PM using portable air monitors and short-term PM and black carbon (BC) using in-home samplers for the seven days preceding nasal fluid collection.

Status of trauma quality improvement programs in the Americas: a survey of trauma care providers.

Introduction: Global disparities in trauma care contribute to significant morbidity and mortality (M&M) in low- and middle-income countries. Implementation of quality improvement (QI) programs has been shown to be a cost-effective strategy to improve trauma care quality. In this study, we aim to characterize the trauma QI programs in a broad range of low- to high-income countries in the Americas to assess areas for targeted improvement in global trauma QI efforts.