Publications by authors named "Hilary C Brown"
Article Synopsis
- The enantioselective syntheses of (-)-coniine, DAB-1, and nectrisine were achieved using a combination of enzyme-catalyzed and transition metal-catalyzed reactions.
- Initial stereocenter creation was highly efficient, achieving over 99% enantioselectivity through enzyme-catalyzed hydrocyanation.
- Challenges with natural enzyme compatibility were addressed by incorporating ruthenium-catalyzed olefin metathesis and employing palladium-catalyzed reactions to produce the desired piperidine and pyrrolidine alkaloid products.
