Publications by authors named "Hilana El-Mekkoussi"
Persistent enterovirus B infection has been proposed as an important contributor to the etiology of type 1 diabetes. We leveraged extensive bulk RNA-sequencing (RNA-seq) data from α-, β-, and exocrine cells, as well as islet single-cell RNA-seq data from the Human Pancreas Analysis Program (HPAP), to evaluate the presence of enterovirus B sequences in the pancreas of patients with type 1 diabetes and prediabetes (no diabetes but positive for autoantibodies). We examined all available HPAP data for either assay type, including donors without diabetes and with type 1 and type 2 diabetes.
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- Multicellular organisms have adapted to have a closed gut, leading to a unique internal microbiome that differs from their environment.
- The study suggests that FOXA transcription factors in vertebrates help shape the gut microbiome by influencing the glycosylation of intestinal epithelial surfaces.
- Deleting FOXA genes results in significant changes to the gut microbial composition and can lead to inflammatory bowel disease, but these changes can be reversed through fecal transplants, highlighting the host's role in gut microbiome management.
Telocyte Recruitment During the Emergence of a Metaplastic Niche in the Stomach.
Cell Mol Gastroenterol Hepatol
July 2024
Background & Aim: Telocytes, a recently identified type of subepithelial interstitial cell, have garnered attention for their potential roles in tissue homeostasis and repair. However, their contribution to gastric metaplasia remains unexplored. This study elucidates the role of telocytes in the development of metaplasia within the gastric environment.
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