Publications by authors named "Hilal M"
Mycosis fungoides (MF) is the most common type of cutaneous T-cell lymphoma (CTCL), representing the majority of all lymphomas arising in the skin. The disease treatment focuses on managing symptoms and preventing disease evolution. To date, there is no gold standard for MF-CTCL treatment.
View Article and Find Full Text PDFBackground: The use of minimally invasive (laparoscopic and robotic) pancreatoduodenectomy (PD) is being increasingly adopted despite the lack of hard evidence to support its utilisation. With recent randomised controlled trials (RCTs) comparing open pancreatoduodenectomy (OPD) with robotic or laparoscopic pancreatoduodenectomy (RPD or LPD), we undertook a network meta-analysis (NMA) comparing all 3 approaches to evaluate comparative outcomes.
Methods: A systematic search of MEDLINE, EMBASE, and Cochrane CENTRAL was conducted up to May 2024 and relevant RCTs were identified.
Objective: To compare nationwide outcomes of robotic liver resection (RLR) with laparoscopic liver resection (LLR).
Background: Minimally invasive liver resection is increasingly performed using the robotic approach as this could help overcome inherent technical limitations of laparoscopy. It is unknown if this translates to improved patient outcomes.
Objective: To validate the ISGPS complexity grading system for minimally invasive pancreaticoduodenectomy (MIPD).
Background: Although concerns about patient safety persist, MIPD is gaining popularity. The ISGPS recently introduced a difficulty grading system to improve patient selection by aligning procedural complexity with surgeon and center expertise.
Background: Tildrakizumab is an interleukin-23 inhibitor approved in Canada in 2021 for the treatment of adults with moderate-to-severe plaque psoriasis.
Objectives: To evaluate real-world effectiveness of tildrakizumab for the treatment of moderate-to-severe plaque psoriasis in Canada.
Methods: A multicenter, retrospective study was conducted in Canada in adults with moderate-to-severe plaque psoriasis for ≥1 year treated with tildrakizumab for ≥12 weeks.
Article Synopsis
- Atopic dermatitis (AD) is a chronic skin condition that can severely affect patients' quality of life, including their sexual well-being.
- A study assessed the impact of moderate-to-severe AD on sexual health and the effectiveness of two treatments, abrocitinib and dupilumab, over a year.
- Results showed that before treatment, a large majority of patients felt their condition affected their sex life negatively, but after 52 weeks of therapy, these negative feelings and behaviors significantly decreased.
Importance: Postoperative pancreatic fistulas (POPF) are the biggest contributor to surgical morbidity and mortality after pancreatoduodenectomy. The impact of POPF could be influenced by the surgical approach.
Objective: To assess the clinical impact of POPF in patients undergoing minimally invasive pancreatoduodenectomy (MIPD) and open pancreatoduodenectomy (OPD).
Grassland which covers 40% of terrestrial land is an important ecosystem having a multitude of functions, which has suffered various degrees of degradation with the interaction between global climate change and unreasonable human utilization (e.g., grazing and reclamation).
View Article and Find Full Text PDFArticle Synopsis
- Autism Spectrum Disorder (ASD) is influenced by genetic, epigenetic, and environmental factors, particularly mutations in the FMR1 gene linked to Fragile X Syndrome (FXS).
- The study used a mouse model to examine how a simulated viral infection (maternal immune activation, MIA) during pregnancy affects the development of ASD-like behaviors in offspring, finding that such exposure led to these behaviors only when it occurred in the womb.
- MIA activation influenced the mGluR1/5-mTOR signaling pathway, impacting learning and memory processes in the hippocampus, but combining MIA with the Fmr1 mutation did not worsen autistic traits, indicating a complex interaction between genetic and environmental factors.
Dermatomyositis (DM) is an idiopathic inflammatory myopathy characterized by progressive muscle weakness and distinctive cutaneous findings. The exact incidence and prevalence of DM in the general population is largely unknown, and data on demographic and clinical features in patients in Canada are lacking. This study aimed to comprehensively evaluate the patients with DM in Southwestern Ontario, Canada.
View Article and Find Full Text PDFBackground: Previous meta-analyses have yielded conflicting results on the optimal surgical treatment strategy in patients with synchronous colorectal liver metastases (sCRLM). This network meta-analysis aims to provide an overview on colorectal-, liver first and simultaneous resections to treat sCRLM.
Methods: A search was conducted in MEDLINE, Embase and Cochrane CENTRAL (inception-July 11,2023).
Porous pure SnO nanofibers (NFs) and LaO nanoparticles (NPs)-embedded porous SnO NFs were successfully synthesized via electrospinning followed by calcination. These materials were systematically evaluated as gas-sensing elements in metal-oxide-semiconductor (MOS) sensors. The LaO NPs embedded in porous SnO NFs demonstrated superior gas-sensing performance compared to pure SnO NFs.
View Article and Find Full Text PDFBackground: Pancreatoduodenectomy in elderly patients may be associated with increased postoperative mortality, but studies in minimally invasive pancreatoduodenectomy (MIPD) are scarce.
Methods: International multicenter retrospective study including patients aged >60 years undergoing MIPD (robot-assisted and laparoscopic) and open pancreatoduodenectomy (OPD), were categorized by age: 60-69, 70-79, and 80+ years. In each category, propensity score matching (PSM) was performed (1:1 ratio) between MIPD and OPD.
We present two pediatric cases of nontraumatic myositis ossificans (MO), which initially mimicked infections, leading to unnecessary treatments. The first case involves an 11-year-old boy with acute left hip pain and swelling, misdiagnosed as a hip joint infection and treated with antibiotics before histology confirmed MO. The second case is a two-year-old girl who presented with limping and restricted hip movement, initially suspected to have septic arthritis.
View Article and Find Full Text PDFObjective: To validate the ISGPS definition and grading system of PPAP after pancreatoduodenectomy (PD).
Summary Background Data: In 2022, the International Study Group for Pancreatic Surgery (ISGPS) defined post-pancreatectomy acute pancreatitis (PPAP) and recommended a prospective validation of its diagnostic criteria and grading system.
Methods: This was a prospective, international, multicenter study including patients undergoing PD at 17 referral pancreatic centers across Europe, Asia, Oceania, and the United States.
Article Synopsis
- Atopic dermatitis can greatly affect pregnant women’s health and quality of life, necessitating effective treatments that ensure safety for both mothers and their babies.
- The systematic review analyzed 13 studies involving 68 patients, leading to findings of 58 live births and 11 spontaneous abortions, indicating that dupilumab therapy can improve dermatitis and has low risks during pregnancy.
- Most pregnancies went smoothly, with 82.4% of deliveries being vaginal and 92.3% of newborns having a normal birth weight, but further research is needed for long-term safety confirmation of dupilumab use in pregnant patients.
Article Synopsis
- * Out of 3,530 patients, 11.6% required conversion, with robotic procedures having a lower conversion rate compared to laparoscopic ones, and conversion associated with various complications, like increased blood loss and longer hospital stays.
- * Emergency conversions showed even more severe outcomes, such as significantly higher blood loss and increased rates of intensive care admissions compared to non-emergency cases.
Article Synopsis
- The study investigates how the length of time taken during liver surgeries affects the likelihood of postoperative complications in patients undergoing different types of liver resections.
- A total of 5,424 patients were analyzed from multiple centers between 2000 and 2022, focusing on procedures like right hemihepatectomy, technically major resection, and left lateral sectionectomy.
- Results show that patients in the longest operative time group had a significantly higher risk of complications, particularly in various surgical approaches like open, laparoscopic, and robotic surgeries.
Article Synopsis
- A new surgery technique called minimally invasive pancreatoduodenectomy (MIPD) is being studied as a possible better option than the traditional open surgery (OPD) for pancreas problems.
- Researchers looked at data from hospitals in North America, Germany, the Netherlands, and Sweden from 2014 to 2020 and found that MIPD is used differently in each country.
- They discovered that more patients were getting MIPD over time, especially in North America and the Netherlands, but there were also higher risks of complications in some cases.