The Effects of Memantine on Cisplatin-Induced Ototoxicity.

Introduction: We aimed to investigate electrophysiologically and histopathologically, the protective effects of intratympanic memantine, an N-methyl-D-aspartate receptor antagonist, on ototoxicity caused by cisplatin, an anti-neoplastic agent used in many types of cancer.

Methods: Thirty-seven guinea pigs with a normal auditory function were randomly allocated to group 1 (cisplatin; n = 8), group 2 (memantine; n = 8), group 3 (cisplatin + memantine; n = 8), group 4 (cisplatin + physiological serum [PS]; n = 8), and group 5 (control; n = 5). Auditory assessments were conducted using distortion product otoacoustic emissions (DPOAE) within a frequency range of 1-32 kHz and auditory brainstem responses (ABRs) within 8-32 kHz.

Development and Validation of the Isotretinoin Hesitancy Scale for Acne Vulgaris: A Preliminary Study.

Background: Oral isotretinoin is the most effective systemic treatment for acne patients who fail to respond to other forms of therapies. However, hesitations and concerns regarding its side effect profile may detain the patients from treatment. This study aimed to develop and validate the Isotretinoin Hesitancy Scale (IHS) among acne patients.

Entomopathogenic nematode detection and counting model developed based on A-star algorithm.

Entomopathogenic nematodes are soil-dwelling living organisms widely employed in the biological control of agricultural insect pests, serving as a significant alternative to pesticides. In laboratory procedures, the counting process remains the most common, labor-intensive, time-consuming, and approximate aspect of studies related to entomopathogenic nematodes. In this context, a novel method has been proposed for the detection and quantification of Steinernema feltiae isolate using computer vision on microscope images.

Efficacy and safety of secukinumab in psoriasis: five-year real life experience.

Background: The efficacy and safety of secukinumab in psoriasis patients has been demonstrated in randomized controlled clinical trials.

Objectives: The authors aimed to evaluate the efficacy and safety of secukinumab in plaque psoriasis patients followed in our clinic.

Methods: Data from 101 plaque psoriasis patients who received at least 16 weeks of secukinumab treatment between June 2018 and June 2023 were retrospectively analyzed.

Evaluation of surface tensions and root-dentin surface contact angles of different endodontic irrigation solutions.

Background: Surface tension and contact angle properties, which play a crucial role in determining the effectiveness of irrigation solutions in penetrating dentin surfaces and dentin tubules, are highly important for the development of new irrigation solutions and their preferences. The aim of the current study was to compare the surface tension and contact angle properties of different irrigation solutions used in endodontics, both on the dentin surface and within dentin tubules.

Methods: In this study, the contact angles and surface tensions of 5.

Evaluation of the Factors Influencing Mortality in Patients with Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: A Multicenter Study of 166 Patients.

Introduction: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are life-threatening acute mucocutaneous disorders usually triggered by drugs. In this study, we aimed to evaluate the factors affecting mortality in patients with SJS-TEN.

Methods: Our study is a retrospective cohort study, analyzing data collected from a total of 12 tertiary care centers between April 2012 and April 2022.

Analysis of clinical characteristics and factors affecting treatment responses in patients with pyoderma gangrenosum: a multicenter study of 239 patients.

Background: Pyoderma Gangrenosum (PG) is a chronic disease characterized by recalcitrant skin ulcers.

Objective: We aimed to evaluate the demographic, clinical characteristics, treatments and factors affecting the treatment responses of patients with PG.

Methods: We performed a multicenter study of 12 tertiary care centers.

Group Movement in Entomopathogenic Nematodes: Aggregation Levels Vary Based on Context.

Maintenance of an aggregated population structure implies within-species communication. In mixed-species environments, species-specific aggregations may reduce interspecific competition and promote coexistence. We studied whether movement and aggregation behavior of three entomopathogenic nematode species changed when isolated, as compared to mixed-species arenas.

Comparison of antimicrobial efficacy of different disinfectants on the biofilm formation in dental unit water systems using dip slide and conventional methods: A pilot study.

Objective: Biofilm formation in dental waterlines brings opportunistic infections, especially for immunosuppressive patients. This study aimed to determine biofilm-forming microorganisms by various methods and investigate disinfectants' effects on biofilm.

Materials & Methods: In the study, samples were obtained from the waterlines of 10-15 aged six dental units, before (0 min.

Epidemiological characteristics of different types of adult acne in Turkey: a prospective, controlled, multicenter study.

Introduction: Acne occurring in adults over the age of 25 years is known as acne tarda or adult acne. Three types of adult acne are recognized: persistent, late-onset, and recurrent acne. Most studies do not compare the characteristics between the three variants.

Narrowband ultraviolet B phototherapy for pityriasis lichenoides: A real-life experience.

Introduction: Pityriasis lichenoides (PL) is a papulosquamous disease affecting both children and adults, for which narrowband-UVB (NB-UVB) phototherapy is regarded as a commonly used treatment option. The aim of this study was to investigate the efficacy of NB-UVB phototherapy in the management of PL and to compare response rates in pediatric and adult age groups.

Materials And Methods: This observational, retrospective study included 20 PL patients (12 pityriasis lichenoides chronica; PLC, 8 pityriasis lichenoides et varioliformis acuta; PLEVA) who failed to respond to other treatment modalities.

Tattoos: Demographics, Motivations, and Regret in Dermatology Patients.

Background: Tattoos are very popular in today's world. Objectives: The aim of this study was to determine the demographics, the characteristics of tattoos, motivations for getting tattoos, tattooing practices and tattoo regret.

Materials And Method: This multi-centre, cross-sectional study was conducted among.

Infected host responses across entomopathogenic nematode phylogeny.

We used a phylogenetic framework to examine the relationship between entomopathogenic nematode (EPN) vertical dispersal and infectivity when EPNs are exposed to a mixture of compounds found in late-stage EPN-infected insect cadavers. EPNs from five phylogenetically close and distant species (, , , and ) were exposed to cadaver macerate produced by their own species' infection and by infected hosts. We found that only three of the five species (, and ) responded to exposure to their own macerate by increasing rates of dispersal.

Evaluation of Healthy Lifestyle Behaviors in Psoriasis Patients.

Objectives: The purpose of our study was to compare healthy lifestyle behaviors between psoriasis patients and healthy controls.

Methods: This case-control study included 80 psoriasis patients and 80 sex- and age- matched healthy controls aged over 18. Participants completed the socio-demographic data form and the Health-Promoting Lifestyle Profile II (HPLP-II).

Cytotoxicity and genotoxicity of salicylate- and calcium silicate-based root canal sealers on primer human periodontal ligament fibroblasts.

The aim of this study was to evaluate the biocompatibility of epoxy-resin-based AHPlus, salicylate-based MTA-Fillapex and calcium silicate-based iRootSP root canal sealers. Cytotoxicity was assessed by XTT test. The extracts from sealers of different setting times were serially diluted.

Prevalence of onychophagia and its relation to stress and quality of life.

Introduction: Onychophagia is defined as putting one's fingers into the mouth and biting the nails. We sought to evaluate the prevalence of onychophagia in university and high school students and its relation to sociodemographic factors, perceived stress, and quality of life.

Methods: A total of 3,475 students were included in the study.

European Standard Series Patch Test Results in Contact Dermatitis Patients in a Tertiary Care Hospital.

Objectives: Sensitization of allergens varies among societies and also it is influenced by various factors, such as age and gender. It may even change over the years. In this study, we aimed to evaluate the patch test results in patients with contact dermatitis (CD) in our center.

Conspecific and heterospecific pheromones stimulate dispersal of entomopathogenic nematodes during quiescence.

Ascaroside pheromones stimulate dispersal, a key nematode behavior to find a new food source. Ascarosides produced by entomopathogenic nematodes (EPNs) drive infective juvenile (IJ) emergence from consumed cadavers and dispersal in soil. Without ascarosides from host cadavers, Steinernema feltiae (EPN) reduce dispersal substantially.

Ustekinumab in psoriasis: Five-year real life experience from a single tertiary centre.

The efficacy and safety of ustekinumab have been demonstrated in randomized clinical trials; however, there are few real-life data evaluating ustekinumab. This observational, retrospective follow-up study included 33 patients with moderate to severe psoriasis vulgaris. Patients were > 18 years old and received at least 16 weeks of ustekinumab.

Anxiety Sensitivity and Quality of Life in Patients with Acne.

Background: Anxiety sensitivity (AS) is a continuous fundamental fear and defined as extreme fear of anxiety sensations and symptoms. High AS can cause tendency to anxiety disorders. There are many studies evaluating the anxiety in patients with acne; however, AS has not been investigated.

The efficacy and safety of omalizumab in refractory chronic spontaneous urticaria: real-life experience in Turkey.

Introduction: This study used real-world data to evaluate the effectiveness and reliability of omalizumab in treating recalcitrant chronic spontaneous urticaria in Turkish patients.

Methods: Study data were collected retrospectively from eight tertiary-care hospitals in Turkey. This study included 132 patients with chronic spontaneous urticaria that were resistant to H1 antihistamine treatment in a dose up to four times the licensed dose and were treated with 300 mg/month of omalizumab for 6 months.

Advanced oxidation protein products and serum total oxidant/antioxidant status levels in rosacea.

Introduction: Rosacea is a chronic, inflammatory dermatosis which develops due to the effect of genetic and environmental factors.

Aim: To evaluate the oxidative stress in rosacea patients by measuring serum total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI) and advanced oxidation protein products (AOPP) levels in our study.

Material And Methods: Our study included rosacea patients and healthy volunteers aged between 18 and 65 years.

The Evaluation of Contact Sensitivity with Standard and Cosmetic Patch Test Series in Rosacea Patients.

Background: Rosacea is a common dermatosis characterized by erythema, telangiectasia, papules and pustules.

Objective: We aimed to evaluate contact sensitivity in the rosacea patients.

Methods: We included 65 rosacea patients and 60 healthy volunteers in the study.