Publications by authors named "Hilal Al Balushi"
Article Synopsis
- Twelve compounds were isolated from the methanolic extract through column chromatography, including three new compounds identified for the first time as natural products.
- Advanced spectroscopic techniques were used to elucidate the structures of these compounds, and their potential as inhibitors of the CA-II enzyme was tested.
- Eleven of the compounds showed significant inhibitory activity against CA-II, with interactions involving a ZN ion and specific amino acid residues crucial for binding.
Bioassay guided isolation of the methanolic extract of marine macro brown alga afforded one new metabolite (ethyl methyl 2-bromobenzene 1,4-dioate, ), one new natural metabolite (diethyl-2-bromobenzene 1,4-dioate, ) along with six known metabolites (-) reported for the first time from this source. The structure elucidation of all these compounds was achieved by extensive spectroscopic techniques including 1D (H and C) and 2D (NOESY, COSY, HMBC and HSQC) NMR and mass spectrometry and comparison of the spectral data of known compounds with those reported in literature. The in vitro α-glucosidase inhibition studies confirmed compound to be the most active against α-glucosidase enzyme with IC value of 30.
View Article and Find Full Text PDFIntra-rater repeatability of gait parameters in healthy adults during self-paced treadmill-based virtual reality walking.
Comput Methods Biomech Biomed Engin
December 2017
Self-paced treadmill walking is becoming increasingly popular for the gait assessment and re-education, in both research and clinical settings. Its day-to-day repeatability is yet to be established. This study scrutinised the test-retest repeatability of key gait parameters, obtained from the Gait Real-time Analysis Interactive Lab (GRAIL) system.
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