Association of Gene Polymorphism with Stroke Patients from Rural Eastern India.

Context: Studies from the different ethnic regions of the world have reported variable results on association of APOE gene polymorphism in stroke.

Aim: The aim of this study is to find out the possible association of APOE polymorphism in stroke patients in ethnic Bengali population.

Settings And Design: A prospective case-control study was undertaken in the Department of Neurology, Burdwan Medical College, Burdwan, West Bengal, India, over a period of 3 years.

Antimutagenic activity of compounds isolated from Wall ex. Benth against EMS induced mutagenicity in mice.

Wall ex. Benth. (Lamiaceae) has been reported to possess many biological activities including antibacterial, antifungal, antispasmodic and antioxidant activity but there is no report as such on its mutagenic and/or anti-mutagenic activity.

Amelioration of the cyclophosphamide induced genotoxic damage in mice by the ethanolic extract of .

In the present study, we evaluated the potential of the plant against the cytotoxic and mutagenic effects induced by cyclophosphamide (chemotherapeutic agent) in the bone marrow cells of mice using the Chromosome assay (CA) and Mitotic index (MI) as the biomarkers. The study was performed following 3 protocols: pre-treatment, simultaneous treatment and post-treatment with the ethanolic extract of the plant. The results demonstrated that the plant extract was not cytotoxic and mutagenic and has a protective effect against the mutagenicity induced by cyclophosphamide in pre, simultaneous and post treatments and against its cytotoxicity as well.