Publications by authors named "Hila Shinar"

Article Synopsis
  • * A dual-dye labeling technique along with advanced microscopy and deep learning was employed to accurately assess BBB opening at a detailed level while saving time in image analysis.
  • * Results showed that nanobubbles significantly improve BBB opening in smaller capillaries compared to traditional microbubbles, while maintaining similar effectiveness in larger blood vessels, highlighting their potential as superior agents for BBB modulation.
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Intrinsically disordered peptide amphiphiles (IDPAs) present a novel class of synthetic conjugates that consist of short hydrophilic polypeptides anchored to hydrocarbon chains. These hybrid polymer-lipid block constructs spontaneously self-assemble into dispersed nanoscopic aggregates or ordered mesophases in aqueous solution due to hydrophobic interactions. Yet, the possible sequence variations and their influence on the self-assembly structures are vast and have hardly been explored.

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Amphiphilic molecules and their self-assembled structures have long been the target of extensive research due to their potential applications in fields ranging from materials design to biomedical and cosmetic applications. Increasing demands for functional complexity have been met with challenges in biochemical engineering, driving researchers to innovate in the design of new amphiphiles. An emerging class of molecules, namely, peptide amphiphiles, combines key advantages and circumvents some of the disadvantages of conventional phospholipids and block copolymers.

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