Publications by authors named "Hila Ra'anani"
Objective: To report the single-center results of orthotopic retransplantations of cryopreserved ovarian tissue in cancer survivors and evaluate the validity of commonly accepted procedure limitations.
Design: Prospective cohort study.
Setting: Tertiary university-affiliated assisted reproduction technology (ART) and oncology centers.
It is clear that ovarian tissue cryopreservation can serve a very important role in providing fertility preservation. To date, more than 30 live human births have resulted from the transplantation of cryopreserved ovarian tissue, proving the successful implementation of this technique. The ideal conditions for ovarian tissue cryopreservation have yet to be determined, indicating the crucial need for more research in this field.
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- Storing ovarian tissue for cancer patients poses a risk of reintroducing malignant cells, prompting the need for improved safety measures in cryopreservation.
- Fifty-eight patients with hematological cancers underwent imaging and histological analysis of ovarian tissue before storage, identifying some pre-existing disease.
- Post-thaw tests for minimal residual disease (MRD) were conducted, revealing that most patients were clear of cancer cells, but one patient’s positive MRD result led to the cancellation of tissue transplantation, highlighting the importance of thorough screening.