Publications by authors named "Hila Nochomovitz"
Background: The parasympathetic system and its main neurotransmitter, acetylcholine, contributes to homeostasis of inflammation. Cholinergic dysregulation is thought to contribute to the pathogenesis of inflammatory rheumatic diseases. Cholinesterase activity in patients with psoriatic arthritis (PsA) has not been investigated.
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- Synovial monocytes (CD14+CD16+) play a key role in the inflammatory responses in patients with psoriatic arthritis (PsA) and rheumatoid arthritis (RA), and the study investigates the impact of different drugs on these cells.
- In laboratory tests, TNF inhibitors (adalimumab and infliximab) significantly decreased the percentage of CD14+CD16+ cells and reduced TNF levels in PsA and RA patients compared to other treatments, such as IL-17 inhibitors and glucocorticoids.
- Additionally, while TNF inhibitors down-regulated inflammatory cytokines and increased anti-inflammatory ones, glucocorticoids had mixed effects, changing the expression of genes related to inflammation differently
Introduction: Vaccination represents a cornerstone in mastering the COVID-19 pandemic. Data on immunogenicity and safety of messenger RNA (mRNA) vaccines in patients with autoimmune inflammatory rheumatic diseases (AIIRD) are limited.
Methods: A multicentre observational study evaluated the immunogenicity and safety of the two-dose regimen BNT162b2 mRNA vaccine in adult patients with AIIRD (n=686) compared with the general population (n=121).