Publications by authors named "Hikaru Ozeki"
Article Synopsis
- * Researchers analyzed 201 CRC patients, identifying different mucin phenotypes and genetic alterations linked to the types of BRAF mutations present.
- * Results showed that distinct mucin expressions and genetic mutations, like APC for non-V600E and RNF43 for V600E, suggest different tumorigenesis pathways, which could inform treatment approaches for BRAF-mutant CRC.
Article Synopsis
- A 44-year-old woman with Lynch syndrome was treated for recurring rectal cancer that had spread to her peritoneum and caused complications like hydronephrosis and a urinary tract infection.
- Initial treatment with pembrolizumab (an immunotherapy) led to significant shrinkage of the tumor and allowed for a subsequent surgery where the metastasis was successfully removed without needing to sacrifice the left ureter.
- This case highlights a successful use of pembrolizumab to convert an initially unresectable tumor to a resectable one, marking a significant advancement in treatment for similar cases.
A 75-year-old woman presented to our hospital with abdominal pain and melena. Colonoscopy revealed an ulcer at the appendiceal orifice. Histopathological examination of biopsy specimens revealed adenocarcinoma.
View Article and Find Full Text PDFBackground: Colorectal cancer (CRC) metastasizes to various organs, while cutaneous metastases are rare. Although there have been several previous reports of axillary cutaneous metastases with other metastases of CRC, there has never been a report of axillary cutaneous metastasis of CRC that could be treated with curative-intent surgery.
Case Presentation: A 68-year-old female was diagnosed with an axillary cutaneous tumor and ascending colon cancer with invasion to the duodenum.
Background: Although previous studies have demonstrated that tumor deposits (TDs) are associated with worse prognosis in colon cancer, their clinical significance in rectal cancer has not been fully elucidated, especially in the lateral pelvic lymph node (LPLN) area. This study aimed to clarify the clinical significance of TDs, focusing on the number of metastatic foci, including lymph node metastases (LNMs) and TDs, in the LPLN area.
Methods: This retrospective study involved 226 consecutive patients with cStage II/III low rectal cancer who underwent LPLN dissection.
A 72-year-old man had a chief complaint of anal pain and difficulty in defecation. He was diagnosed with adenocarcinoma by biopsy from a tumor of the anal canal. A computed tomography scan revealed neither regional lymph node metastasis nor distant metastasis.
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