Publications by authors named "Hikaru Murakami"
Article Synopsis
- The study compares the oncological outcomes of sentinel lymph node biopsy (SNB) and pelvic lymphadenectomy (PLD) in patients with early-stage cervical cancer.
- A total of 104 patients, with tumor sizes mainly ≤2 cm, underwent laparoscopic or robot-assisted radical hysterectomy, showing that only one patient in the SNB group had lymph node metastasis compared to nine in the PLD group.
- Follow-up results indicated a 100% disease-free survival (DFS) rate for the SNB group and a 91.5% rate for the PLD group, suggesting that SNB is adequate for patients with smaller tumors, potentially making PLD unnecessary.
: The application of personalized cancer treatment based on genetic information and surgical samples has begun in the field of cancer medicine. However, a biopsy may be painful for patients with advanced diseases that do not qualify for surgical resection. Patient-derived xenografts (PDXs) are cancer models in which patient samples are transplanted into immunodeficient mice.
View Article and Find Full Text PDFPatient-derived xenograft (PDX) models retain the characteristics of tumors and are useful tools for personalized therapy and translational research. In this study, we aimed to establish PDX models for uterine corpus malignancies (UC-PDX) and analyze their similarities. Tissue fragments obtained from 92 patients with uterine corpus malignancies were transplanted subcutaneously into immunodeficient mice.
View Article and Find Full Text PDFBackground: Congenital heart disease occurs in approximately 1 in 100 cases. Although sibling occurrence is high (3-9%), the causative genes for this disease are still being elucidated. PLD1 (Phospholipase D1) is a recently discovered gene; however, few case reports have been published on it.
View Article and Find Full Text PDFBackground: At the time of benign gynecological surgery, a prophylactic salpingo-oophorectomy or salpingectomy is increasingly being performed concurrently to reduce the risk of future ovarian and fallopian tube cancer. We herein describe a case of hereditary breast and ovarian cancer syndrome in which a hysterectomy and bilateral adnexectomy were performed with a preoperative diagnosis of benign tumor. A detailed pathological examination revealed occult fallopian tube cancer, and additional staging surgery provided an accurate pathology diagnosis.
View Article and Find Full Text PDFArticle Synopsis
- This study compares lymphatic complications in patients with endometrial cancer who underwent sentinel node biopsy (SNB) versus pelvic lymphadenectomy (LND) from September 2012 to April 2022.
- Out of 388 patients, those who had SNB experienced significantly lower rates of lower-extremity lymphedema (LEL) at 2.0% compared to 21.3% in the pelvic LND group.
- Additionally, no patients in the SNB group developed pelvic lymphocele (PL), while 2.1% of the pelvic LND group did, highlighting SNB's lower risk for lymphatic complications overall.
Aims: Medroxyprogesterone acetate (MPA) is the most common fertility-sparing treatment in patients with early-stage endometrial cancer. If MPA treatment fails, hysterectomy is recommended. Thus, there is an urgent need for novel treatment approaches for MPA-resistant endometrial cancer patients who wish to preserve their fertility.
View Article and Find Full Text PDFArticle Synopsis
- * This study focuses on identifying cancer-specific miRNAs in extracellular vesicles (Te-EVs) collected from patients with OCC, comparing them to normal ovarian tissue.
- * The research found 37 miRNAs significantly elevated in OCC tissue, with 6 showing decreased levels post-surgery, suggesting these miRNAs could serve as promising biomarkers for early OCC diagnosis.