Publications by authors named "Hikaru K Ishibashi"
Background: This study aimed to investigate whether arithmetic hip-knee-ankle angle (aHKA) can be a surrogate for valgus stress radiography (VSR). Furthermore, we investigated the optimal cutoff values for preoperative radiographic parameters, thereby validating the appropriate inclusion criteria for prearthritic/kinematic unicompartmental knee arthroplasty (prearthritic-UKA).
Methods: We retrospectively analyzed 123 patients who underwent medial UKA.
Rheumatoid fibroblast-like synoviocytes (RFLS) have an important role in the inflammatory pathogenesis of rheumatoid arthritis (RA). Toll-like receptor 3 (TLR3) is upregulated in RFLS; its activation leads to the production of interferon-β (IFN-β), a type I IFN. IFN-stimulated gene 56 (ISG56) is induced by IFN and is involved in innate immune responses; however, its role in RA remains unknown.
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- Innate immunity plays a role in synovitis in rheumatoid arthritis (RA), but the specific molecular mechanisms are not fully understood, particularly regarding DDX60, a potential RNA helicase involved in inflammation.
- In a study, DDX60 protein expression was found to be significantly higher in synovial tissues from RA patients compared to those with osteoarthritis (OA), indicating its potential involvement in RA.
- The research demonstrated that TLR3 signaling can stimulate DDX60 expression in rheumatoid fibroblast-like synoviocytes, which in turn influences the production of CXCL10, a molecule important for attracting immune cells, suggesting DDX60's role in RA-related synovial inflammation.
Background: Bone marrow lesion (BML) is an important magnetic resonance finding (MRI) finding that predicts knee osteoarthritis. The purpose of this study was to investigate the influence of proximal tibial morphology on BML, including the spreading root sign (SRS), in women without radiographic knee osteoarthritis (OA). It was hypothesized that varus alignment and a greater posterior tibial slopes (PTS) are associated with BML.
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