Publications by authors named "Hikari Kono"
Biol Pharm Bull
September 2020
Article Synopsis
- The study investigated how catecholamine metabolites affect smooth muscle relaxation in tracheas and aorta of different animals, revealing that metadrenaline notably relaxed guinea pig trachea.
- In the presence of enzyme inhibitors, normetadrenaline and metadrenaline showed mixed effects on isoprenaline-induced relaxation, highlighting their complex interactions.
- The findings suggest that these metabolites can either enhance or inhibit β-adrenoceptor-mediated relaxation, potentially contributing to conditions like pheochromocytoma associated with high catecholamine levels.
