Synthesis, Characterization and Catalytic/Antimicrobial Activities of Some Transition Metal Complexes Derived from 2-Floro-N-((2-Hydroxyphenyl)Methylene)Benzohydrazide.

Background: In the last few decades, the field of coordination chemistry has grown very fast, especially in the fields of pharmaceutical, biological and catalytic studies. In ancient times, metals were thought to be beneficial to health issues but nowadays the link between organic-metal substances and different industrial and medicinal properties is well established.

Methods: A Schiff base ligand (2-fluoro-N'-[(E)-2-hydroxyphenyl) methylene] benzohydrazide) was reacted with a series of transition metals to produce complexes with a general formula [ML(NO)]NO.

Optimizing Outcomes in Heart Transplantation: The Role of High-Intensity Statin Therapy.

Heart transplantation is a vital procedure for patients with end-stage heart failure, but it faces significant challenges, including graft dysfunction, rejection, and cardiac allograft vasculopathy (CAV), which can compromise long-term graft success. Research suggests that statin therapy may offer significant benefits to heart transplant recipients, such as improved long-term survival and reduced rates of graft rejection and mortality. The aim of this review is to thoroughly examine the recent literature on this topic since 2005.

Evaluating the impact of different biochar types on wheat germination.

This study assessed sustainable solutions for organic waste management, focusing on biochar derived from kitchen waste. The characteristics and phytotoxicity effects of biochar produced from four different types of kitchen waste were investigated in view of potential agricultural applications. Analysis of the chemical and physical properties of the different biochar samples by X-ray fluorescence and Fourier transform infrared spectroscopy revealed a nutrient-rich composition with carbon, calcium, and potassium contents that ranged from 35 to 48%, from 1.

Data losses and synchronization according to delay in PLC-based industrial automation systems.

PLC (Programmable Logic Controllers) based data collection is integral to industrial automation and data acquisition processes. The pipeline - between the device and the database - is a complex system with many components and often causes some time delay, due to the synchronization and the applied hardware and software components. This delay can also lead to data loss on the database site.

pH-sensing GPR68 inhibits vascular smooth muscle cell proliferation through Rap1A.

Phenotypic transformation of vascular smooth muscle (VSM) from a contractile state to a synthetic, proliferative state is a hallmark of cardiovascular disease (CVD). In CVD, diseased tissue often becomes acidic from altered cellular metabolism secondary to compromised blood flow, yet the contribution of local acid/base imbalance to the disease process has been historically overlooked. In this study, we examined the regulatory impact of the pH-sensing G protein-coupled receptor GPR68 on vascular smooth muscle (VSM) proliferation in vivo and in vitro in wild-type (WT) and GPR68 knockout (KO) male and female mice.

Utilizing in removing methylene blue dye from water: an effective approach.

Removing dyes, particularly methylene blue, from wastewater is crucial due to their detrimental effects on environmental and human health. Adsorption, recognized as a simple and efficient technique, is frequently employed to eliminate various dyes from water. Although activated carbon is a favored adsorbent for wastewater treatment, its high cost often restricts its use.

Predictors of 30-Day Mortality and Morbidity Following Craniotomy for Traumatic Brain Injury: An ACS NSQIP Database Analysis.

Traumatic brain injury (TBI) is the leading cause of death among trauma patients. Identifying preoperative factors that predict postoperative outcomes in such patients can guide surgical decision-making. The aim of this study was to develop a predictive model using preoperative variables that predicts 30-day mortality and morbidity in patients undergoing neurosurgery following TBI.

Comprehensive Review of : Development, Bioactive Properties, and Therapeutic Applications.

Plants are being researched as potential sources of novel drugs, which has led to a recent acceleration in the discovery of new bioactive compounds. Research on tissue culture technology for the synthesis and processing of plant compounds has skyrocketed, surpassing all expectations. These plants can be bought either raw or as extracts, where some of the chemicals are extracted by mashing the plant in water, alcohol, or another solvent.

Comparing Conventional and Advanced Approaches for Heavy Metal Removal in Wastewater Treatment: An In-Depth Review Emphasizing Filter-Based Strategies.

Various industrial activities release heavy metal ions into the environment, which represent one of the major toxic pollutants owing to their severe effects on the environment, humans, and all living species. Despite several technological advances and breakthroughs, wastewater treatment remains a critical global issue. Traditional techniques are dedicated to extracting heavy metal ions from diverse wastewater origins, encompassing coagulation/flocculation, precipitation, flotation, and ion exchange.

UPC2 mutations and development of azole resistance in Candida albicans hospital isolates from Lebanon.

Objectives: This study evaluated the role of Upc2 in the development of azole resistance in Candida albicans isolates from Lebanese hospitalized patients and determined a correlation between resistance and virulence.

Methods: The UPC2 gene which codes for an ergosterol biosynthesis regulator was sequenced and analysed in two azole-resistant and one azole-susceptible C. albicans isolates.

Biomarker Testing Disparities in Metastatic Colorectal Cancer.

Importance: Among patients with metastatic colorectal cancer (mCRC), data are limited on disparate biomarker testing and its association with clinical outcomes on a national scale.

Objective: To evaluate the socioeconomic and demographic inequities in microsatellite instability (MSI) and KRAS biomarker testing among patients with mCRC and to explore the association of testing with overall survival (OS).

Design, Setting, And Participants: This cohort study, conducted between November 2022 and March 2024, included patients who were diagnosed with mCRC between January 1, 2010, and December 31, 2017.

Enhancing Wastewater Depollution: Sustainable Biosorption Using Chemically Modified Chitosan Derivatives for Efficient Removal of Heavy Metals and Dyes.

Driven by concerns over polluted industrial wastewater, particularly heavy metals and dyes, this study explores biosorption using chemically cross-link chitosan derivatives as a sustainable and cost-effective depollution method. Chitosan cross-linking employs either water-soluble polymers and agents like glutaraldehyde or copolymerization of hydrophilic monomers with a cross-linker. Chemical cross-linking of polymers has emerged as a promising approach to enhance the wet-strength properties of materials.

Epigenetic underpinnings of the autistic mind: Histone modifications and prefrontal excitation/inhibition imbalance.

Autism spectrum disorder (ASD) is complex neurobehavioral condition influenced by several cellular and molecular mechanisms that are often concerned with synaptogenesis and synaptic activity. Based on the excitation/inhibition (E/I) imbalance theory, ASD could be the result of disruption in excitatory and inhibitory synaptic transmission across the brain. The prefrontal cortex (PFC) is the chief regulator of executive function and can be affected by altered neuronal excitation and inhibition in the course of ASD.

Digital Pathology for Better Clinical Practice.

(1) Background: Digital pathology (DP) is transforming the landscape of clinical practice, offering a revolutionary approach to traditional pathology analysis and diagnosis. (2) Methods: This innovative technology involves the digitization of traditional glass slides which enables pathologists to access, analyze, and share high-resolution whole-slide images (WSI) of tissue specimens in a digital format. By integrating cutting-edge imaging technology with advanced software, DP promises to enhance clinical practice in numerous ways.

Principles of risk assessment in colon cancer: immunity is key.

In clinical practice, the administration of adjuvant chemotherapy (ACT) following tumor surgical resection raises a critical dilemma for stage II colon cancer (CC) patients. The prognostic features used to identify high-risk CC patients rely on the pathological assessment of tumor cells. Currently, these factors are considered for stratifying patients who may benefit from ACT at early CC stages.

Clinico-pathologic factors and survival of patients with breast cancer diagnosed with de novo brain metastasis: a national cancer database analysis.

Purpose: Patients with Breast Cancer (BC) with Brain Metastasis (BCBM) have poor survival outcomes. We aimed to explore the clinico-pathologic and therapeutic factors predicting the survival in patients with de novo BCBM using the National Cancer Database (NCDB).

Patients And Methods: The NCDB was queried for patients with BC between 2010 and 2020.

Design and Synthesis of Novel Amino and Acetamidoaurones with Antimicrobial Activities.

The development of new and effective antimicrobial compounds is urgent due to the emergence of resistant bacteria. Natural plant flavonoids are known to be effective molecules, but their activity and selectivity have to be increased. Based on previous aurone potency, we designed new aurone derivatives bearing acetamido and amino groups at the position 5 of the A ring and managing various monosubstitutions at the B ring.

Recent advances in nanomaterial-based biosensor for periodontitis detection.

Periodontitis, a chronic inflammatory condition caused by bacteria, often causes gradual destruction of the components that support teeth, such as the alveolar bone, cementum, periodontal ligament, and gingiva. This ultimately results in teeth becoming loose and eventually falling out. Timely identification has a crucial role in preventing and controlling its progression.

Regenerative potential of platelet concentrates in chronic oral mucosal lesions.

Chronic oral mucosal diseases (COMDs) represent a significant challenge for clinicians and patients. They are commonly associated with chronic pain and negative effects on healing and patient's quality of life. Regenerative medicine including the use of biological autologous blood-derived substances (e.

Histopathological Tracing of HPV Genotypes 6 and 11 in Pediatric Patients in Medical City with Chronic Palatine and Pharyngeal Tonsillitis.

Background: HPVs are considered to have high-oncogenic risk. These genotypes have been proven to have a causal link to cancers, in pediatric and youth patients, with high rates of HPV presence in the tonsillar tissues.

Objective: A prospective case-control research for determining HPV 6/11 genotypes in tonsillar specimens of children who underwent operations in the otolaryngology departments of the Medical City Complex, Baghdad, Iraq, for their non-oncologic palatine and pharyngeal tonsillar hypertrophies.

Novel immunotherapeutic options for BCG-unresponsive high-risk non-muscle-invasive bladder cancer.

Background: High-risk non-muscle-invasive bladder cancer (HR-NMIBC) presents a challenge to many physicians due to its ability to resist Bacillus Calmette-Guérin (BCG) intravesical therapy and the substantial rate of progression into muscle-invasive bladder cancer (MIBC). Patients who are BCG-unresponsive have worse prognosis and thus require further management including radical cystectomy (RC), which significantly impacts quality of life. Moreover, the ongoing worldwide shortage of BCG warrants the need for policies that prioritize drug use and utilize alternative treatment strategies.

Exploring Hydrogen Sources in Catalytic Transfer Hydrogenation: A Review of Unsaturated Compound Reduction.

Catalytic transfer hydrogenation has emerged as a pivotal chemical process with transformative potential in various industries. This review highlights the significance of catalytic transfer hydrogenation, a reaction that facilitates the transfer of hydrogen from one molecule to another, using a distinct molecule as the hydrogen source in the presence of a catalyst. Unlike conventional direct hydrogenation, catalytic transfer hydrogenation offers numerous advantages, such as enhanced safety, cost-effective hydrogen donors, byproduct recyclability, catalyst accessibility, and the potential for catalytic asymmetric transfer hydrogenation, particularly with chiral ligands.

Loading of Silver (I) Ion in L-Cysteine-Functionalized Silica Gel Material for Aquatic Purification.

The L-cysteine-functionalized silica (SG-CysNa) matrix was effectively loaded with silver (I) ions using the batch sorption technique. Optimal Ag(I) loading into SG-CysNa reached 98% at H = 6, 80 rpm, 1 mg L, and a temperature of 55 °C. The Langmuir isotherm was found to be suitable for Ag(I) binding onto SG-CysNa active sites, forming a homogeneous monolayer ( = 0.