Sex-Specific changes in stress circuitry of the nucleus tractus solitarius following food deprivation in two rat strains.

Food deprivation is used in many experimental models and is becoming increasingly prevalent in human diets. The impact of food deprivation on specific brain regions, including the nucleus of the tractus solitarius (NTS), a region that is involved in hunger and satiety sensing, remains to be determined. The NTS is a heterogeneous nucleus that includes corticotropin releasing factor receptor 1 (CRF1) neurons.

Parent perspectives on education to support hospital discharge for children with invasive mechanical ventilation.

Background: Children with invasive mechanical ventilation (IMV) often live at home, but for safety, parents must be prepared to assume primary responsibility for all aspects of their child's medically complex care. Prior studies have described discharge education programs, however often without perspectives of parents with lived experience transitioning home.

Purpose: To describe parent perspectives on hospital-based education for discharging home a child with IMV.

Increased reactivity of the paraventricular nucleus of the hypothalamus and decreased threat responding in male rats following psilocin administration.

Psychedelics have experienced renewed interest following positive clinical effects, however the neurobiological mechanisms underlying effects remain unclear. The paraventricular nucleus of the hypothalamus (PVN) plays an integral role in stress response, autonomic function, social behavior, and other affective processes. We investigated the effect of psilocin, the psychoactive metabolite of psilocybin, on PVN reactivity in Sprague Dawley rats.

Chronic Alcohol Drinking Drives Sex-Specific Differences in Affective Behavior and Medial Prefrontal Cortex Activity in CRF1:Cre:tdTomato Transgenic Rats.

In 2021, 131 million adult Americans reported drinking alcohol in the last month, despite the well-known consequences of alcohol consumption. While alcohol use disorders (AUDs) are associated with both mood and chronic pain disorders, the relationship between alcohol drinking and affective and nociceptive behaviors remains unclear. Corticotropin releasing factor receptor-1 (CRF1) has been implicated in alcohol drinking, affective states, and pain sensitivity, often in a sex-dependent manner.

Hydrotalcite-Derived Copper-Based Oxygen Carrier Materials for Efficient Chemical-Looping Combustion of Solid Fuels with CO Capture.

Chemical-looping combustion (CLC) is a promising technology that utilizes metal oxides as oxygen carriers for the combustion of fossil fuels to CO and HO, with CO readily sequestrated after the condensation of steam. Thermally stable and reactive metal oxides are desirable as oxygen carrier materials for the CLC processes. Here, we report the performance of Cu-based mixed oxides derived from hydrotalcite (also known as layered double hydroxides) precursors as oxygen carriers for the combustion of solid fuels.

Precursor engineering of hydrotalcite-derived redox sorbents for reversible and stable thermochemical oxygen storage.

Chemical looping processes based on multiple-step reduction and oxidation of metal oxides hold great promise for a variety of energy applications, such as CO capture and conversion, gas separation, energy storage, and redox catalytic processes. Copper-based mixed oxides are one of the most promising candidate materials with a high oxygen storage capacity. However, the structural deterioration and sintering at high temperatures is one key scientific challenge.

Parent education programs for children assisted by invasive mechanical ventilation: A scoping review.

Problem: The population of children assisted by invasive mechanical ventilation (IMV) and living at home is growing. Although parent education is essential for safe transitions from hospital-to-home, little is known about how this education is delivered. The aim of this review is to identify existing literature about parent education programs, synthesize the evidence, and identify gaps in the literature for future inquiry.

Hydrogen Production and Its Applications to Mobility.

Hydrogen has been identified as one of the key elements to bolster longer-term climate neutrality and strategic autonomy for several major countries. Multiple road maps emphasize the need to accelerate deployment across its supply chain and utilization. Being one of the major contributors to global CO emissions, the transportation sector finds in hydrogen an appealing alternative to reach sustainable development through either its direct use in fuel cells or further transformation to sustainable fuels.

Dual-layer spectral CT virtual-non-contrast images aid in parathyroid adenoma analysis and radiation dose reduction: confirmation of findings from dual-energy CT.

4D-parathyroid CT scans have become a mainstay in the evaluation and pre-surgical planning for parathyroid adenomas. Most protocols typically rely on non-contrast images, prior to the arterial and delayed phases. Previous reports with dual-energy CT imaging have highlighted the utility of virtual non-contrast images to help reduce radiation dose while maintaining diagnostic accuracy.

Juvenile Neuromuscular Systems Show Amplified Disturbance to Muscle Unloading.

Muscle unloading results in severe disturbance in neuromuscular function. During juvenile stages of natural development, the neuromuscular system experiences a high degree of plasticity in function and structure. This study aimed to determine whether muscle unloading imposed during juvenile development would elicit more severe disruption in neuromuscular function than when imposed on fully developed, mature neuromuscular systems.

Sensitivity of subcellular components of neuromuscular junctions to decreased neuromuscular activity.

Muscle unloading imparts subtotal disuse on the neuromuscular system resulting in reduced performance capacity. This loss of function, at least in part, can be attributed to disruptions at the neuromuscular junction (NMJ). However, research has failed to document morphological remodeling of the NMJ with short term muscle unloading.

Toll-like receptor 4-mediated respiratory syncytial virus disease and lung transcriptomics in differentially susceptible inbred mouse strains.

Respiratory syncytial virus (RSV) causes severe lower respiratory tract disease in infants, young children, and susceptible adults. The pathogenesis of RSV disease is not fully understood, although toll-like receptor 4 (TLR4)-related innate immune response is known to play a role. The present study was designed to determine TLR4-mediated disease phenotypes and lung transcriptomics and to elucidate transcriptional mechanisms underlying differential RSV susceptibility in inbred strains of mice.

Determinants of host susceptibility to murine respiratory syncytial virus (RSV) disease identify a role for the innate immunity scavenger receptor MARCO gene in human infants.

Background: Respiratory syncytial virus (RSV) is the global leading cause of lower respiratory tract infection in infants. Nearly 30% of all infected infants develop severe disease including bronchiolitis, but susceptibility mechanisms remain unclear.

Methods: We infected a panel of 30 inbred strains of mice with RSV and measured changes in lung disease parameters 1 and 5days post-infection and they were used in genome-wide association (GWA) studies to identify quantitative trait loci (QTL) and susceptibility gene candidates.

American College Of Radiology/Society of Breast Imaging curriculum for resident and fellow education in breast imaging.

The ACR and the Society of Breast Imaging have revised the curriculum for resident and fellow education in breast imaging on the basis of substantial changes in breast imaging practice since the initial curriculum was published in 2000. This curriculum provides guidance to academic chairs, residency program directors, and academic section chiefs in assessing and improving their residency and fellowship training programs and indicates to residents and breast imaging fellows the topics they need to learn and the experience they should try to acquire during their training. Radiologists already in practice also may find the curriculum useful in outlining the material they need to know to remain up to date in the practice of breast imaging.

Reproducibility of heel ultrasound measurement in prepubescent children: lack of influence of ethnicity, sex, or body size.

Objective: There is a growing demand for assessment of bone status in children. Among the techniques currently available, quantitative ultrasound measurement is attractive because of its lower cost, portability, and safety. However, factors influencing its reproducibility in children remain an issue.

Antireflection coatings designed for two different infrared substrates.

It is shown that it is possible to design normal-incidence antireflection coatings that simultaneously reduce the reflectance of two different substrates. Although this is at the expense of some deterioration in performance when compared with that of conventional coatings, it can lead to significant time and cost savings in small thin-film production facilities. Numerical examples are presented for ZnS/ZnSe, Si/Ge, and ZnS/Ge substrate pairs.

Demographic characteristics of physicists who evaluate mammographic units.

Purpose: To determine whether there will be an adequate number of physicists to meet the 1996 American College of Radiology (ACR) Mammography Accreditation Program requirements and assess the qualifications of physicists available to evaluate mammography units as required by the federal Mammography Quality Standards Act of 1992.

Materials And Methods: A 21-question survey prepared by the ACR was sent to most medical physicists who perform evaluations of mammographic units. Replies were received from 1,011 individuals.

Methemoglobin reductase deficiency in a cat.

During ovariohysterectomy of a 6-month-old domestic shorthair cat, extravasated blood appeared brown. Methemoglobinemia was considered likely on the basis of discoloration of oxygenated blood. The absence of clinical signs of toxicosis, inability to identify a source of oxidant that could cause methemoglobinemia, and persistence of cyanotic-appearing tongue and mucous membranes in this cat made a drug-induced cause unlikely, and was suggestive of a congenital disorder.

Performance of automatic exposure controls when used with rare-earth intensifying screens.

The performance of four phototiming systems was evaluated for use with six different intensifying screens. Phototimer response was studied as a function of patient thickness, kVp, field size, and exposure time. Each system demonstrated a sufficient range of sensitivity to produce acceptable film densities with all screens using an average-sized phantom; three systems produced overexposures of thin phantoms with almost all screens.