Bioequivalent antiepileptic drug switching and the risk of seizure-related events.

Background: Older antiepileptic drugs (AEDs) are known to have a narrow therapeutic index. As a consequence, switching between bioequivalent AEDs remains controversial in the management of epilepsy. We investigated the association between A-rated switching of each class of currently available AED and emergent treatment for a seizure-related event.

Natural history of branch retinal vein occlusion: an evidence-based systematic review.

Objective: To describe the natural history of branch retinal vein occlusion (BRVO) based on the best available evidence from the literature.

Clinical Relevance: Branch retinal vein occlusion is the second most frequent major retinal vascular disease. Although several new treatments for BRVO are currently being introduced, data on its natural history are sparse.

Natural history of central retinal vein occlusion: an evidence-based systematic review.

Objective: To describe the natural history of central retinal vein occlusion (CRVO) based on the best available evidence from the literature.

Clinical Relevance: Central retinal vein occlusion is a common sight-threatening retinal vascular disease. Despite the introduction of new interventions, the natural history of CRVO is unclear.

Association between mobility mode and C-reactive protein levels in men with chronic spinal cord injury.

Objective: To assess clinical determinants of systemic inflammation in persons with chronic spinal cord injury (SCI).

Design: Cross-sectional survey.

Setting: Veterans Affairs medical center.