Publications by authors named "Hien T T Lai"
The pandemic of COVID-19 severe acute respiratory syndrome, which was fatal for millions of people worldwide, triggered the race to understand in detail the molecular mechanisms of this disease. In this work, the differences of interactions between the SARS-CoV/SARS-CoV-2 Receptor binding domain (RBD) and the human Angiotensin Converting Enzyme 2 (ACE2) receptor were studied using in silico tools. Our results show that SARS-CoV-2 RBD is more stable and forms more interactions with ACE2 than SARS-CoV.
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- The translocator protein (TSPO), an 18kDa mitochondrial protein, is overexpressed in tumor cells and neuroinflammation, making it a key biomarker and drug target.
- Researchers developed a model of human TSPO in both an unbound state and in complex with PK11195, a molecule used in PET imaging, to study its structural interactions.
- Molecular dynamics simulations revealed that PK11195 stabilizes TSPO and alters cholesterol binding patterns, suggesting a potential new focus for experimental studies on the CRAC-like motif in TSPO's structure.