Publications by authors named "Hien T Bui"
Detection of Antiretroviral Drug-Resistant Mutations and HIV-1 Subtypes in Circulation Among Men Who Have Sex With Men, SEM Females, and Female Sex Workers: Results of Vietnam's HIV Sentinel Surveillance Plus System, 2018-2020.
J Acquir Immune Defic Syndr
January 2025
Article Synopsis
- HIV drug resistance (HIVDR) can decrease the effectiveness of antiretroviral drugs, and this study focused on assessing HIV-1 subtypes and drug resistance among key populations in Vietnam during 2018 and 2020.
- The study recruited participants from hotspots for men who have sex with men (MSM) and female sex workers (FSW) in various provinces, and 42.5% of HIV-positive samples had a viral load indicating the need for further testing for drug resistance.
- The results showed that CRF01_AE was the most common subtype, and 16.7% of participants had drug resistance mutations, with the majority being associated with NNRTI and NRTI classes, suggesting
Article Synopsis
- This study developed multiplex real-time PCR methods using SYBR Green and TaqMan probes to quickly and accurately diagnose three types of pathogenic Yersinia: highly pathogenic Y. enterocolitica, low pathogenic Y. enterocolitica, and Y. pseudotuberculosis.
- Specific primers and probes were created from three distinct genes to differentiate these Yersinia groups and were tested on 26 strains to ensure specificity.
- The developed methods proved effective in detecting low levels of Yersinia DNA in various samples, enhancing capabilities for monitoring and understanding the epidemiology of these pathogens.
Article Synopsis
- Cytokinin is vital for plant stress responses, particularly in drought conditions, and involves a signaling pathway with histidine phosphotransfer proteins (HPs).
- The study reveals that AHP4 is essential for drought resistance in Arabidopsis thaliana, showing that AHP4 knockout plants have higher survival rates and better physiological adaptations compared to wild-type plants during drought stress.
- The research identifies that AHP4 influences the expression of genes linked to drought response and enhances traits like increased wax accumulation, leaf cuticle thickness, and oxidative stress management, underscoring its key role in plant drought adaptation.
From July 2017 to Jan 2019, a total of 572 retail fresh vegetables were collected to clarify the contamination of Salmonella in the Mekong Delta, Vietnam. Salmonella was isolated from 74 (12.9%) of 572 samples.
View Article and Find Full Text PDFBackground: CRISPR/Cas9 gene editing is now revolutionizing the ability to effectively modify plant genomes in the absence of efficient homologous recombination mechanisms that exist in other organisms. However, soybean is allotetraploid and is commonly viewed as difficult and inefficient to transform. In this study, we demonstrate the utility of CRISPR/Cas9 gene editing in soybean at relatively high efficiency.
View Article and Find Full Text PDFArticle Synopsis
- - The study aimed to assess the prevalence of pretreatment drug resistance (PDR) to first-line antiretroviral drugs among HIV patients starting treatment in Vietnam, with data collected from 2009 to 2010 across various clinics.
- - Out of 490 participants with detectable viral loads, 3.5% exhibited drug-resistance mutations, with a higher prevalence found in individuals who injected drugs (4.0%) compared to those with sexually acquired HIV (1.4%).
- - The findings suggest that PDR to first-line antiretroviral drugs is low in Vietnam, indicating that first-line treatments are likely effective, though ongoing monitoring and prevention strategies are necessary to maintain this low resistance rate.
Background: An estimated 120,000 HIV-associated cryptococcal meningitis (CM) cases occur each year in South and Southeast Asia; early treatment may improve outcomes. The World Health Organization (WHO) recently recommended screening HIV-infected adults with CD4<100 cells/mm(3) for serum cryptococcal antigen (CrAg), a marker of early cryptococcal infection, in areas of high CrAg prevalence. We evaluated CrAg prevalence and cost-effectiveness of this screening strategy in HIV-infected adults in northern and southern Vietnam.
View Article and Find Full Text PDFThis single-center retrospective pilot program's objective was to utilize outpatient pharmacists to improve laboratory test adherence in chronic heart failure (CHF) patients overdue for thyroid function testing, thereby demonstrating the value of the outpatient pharmacist and justifying possible clinical role expansion. Thyroid disorders may contribute to CHF development, progression, and exacerbation. Testing is the standard of care in CHF patients per American Heart Association's 2009 Guidelines.
View Article and Find Full Text PDFPatients with mechanical heart valves (MHVs) are at a higher risk for thromboembolic events than patients with atrial fibrillation (AF). This difference is observed in the higher maintenance international normalized ratio (INR) range for patients with MHV and in the selection for anticoagulation bridge therapy when warfarin is interrupted perioperatively. However, once the decision is made to "bridge," the same therapeutic options, unfractionated heparin and subcutaneous low-molecular-weight heparin (LMWH), are applicable to the 2 patient populations.
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