Publications by authors named "Hidetoshi Nomura"
Article Synopsis
- The study investigates two aggressive types of hepatocellular carcinoma (HCC): macrotrabecular massive (MTM) pattern and vessels encapsulating tumor clusters (VETC) pattern, focusing on their immunophenotypes and tumor immune microenvironment (TIME).
- It analyzes 74 cases of previously diagnosed HCC, revealing that MTM-HCC has distinct characteristics, including higher PD-L1 expression (associated with immune suppression) compared to VETC-HCC and conventional HCC.
- Findings suggest that although both patterns exhibit an immunosuppressive TIME, they consist of different elements, and transitioning TIME from suppressive to active could improve the efficacy of immune checkpoint inhibitors in treatment.
The relationship between cancer stem cells (CSCs) in oral squamous cell carcinoma (OSCC) and programmed cell death ligand 1 (PD-L1)/programmed cell death 1 (PD-1) remains unclear. Therefore, the present study aimed to clarify the association between the CD44v3/CD24 immunophenotype of CSCs in OSCC and PD-L1/PD-1 co-expression, and to assess the prognostic effect of CSCs in terms of immune checkpoint molecules. Formalin-fixed, paraffin-embedded tissue samples and clinicopathological data from 168 patients with OSCC were retrospectively retrieved.
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