Diminishing dry weight is strongly associated with all-cause mortality among long-term maintenance prevalent dialysis patients.

Objectives: To investigate the relationship between dry weight (DW) change and survival in long-term maintenance prevalent dialysis patients.

Methods: We conducted a prospective data collection study with retrospective analysis of the registered data. Patients were followed up for 5 years (1-year observation of DW changes and subsequent 4-year follow-up).

N-terminal-pro-B-type-natriuretic peptide associated with 2-year mortality from both cardiovascular and non-cardiovascular origins in prevalent chronic hemodialysis patients.

N-terminal-pro-B-type-natriuretic peptide (NT-proBNP) was a predictive marker of cardiovascular disease (CVD)-related death in chronic dialysis patients. NT-proBNP was also correlated with markers of inflammation, malnutrition and protein-energy wasting. We hypothesized whether NT-proBNP was also associated with non-CVD death in chronic dialysis patients.

Risk of Cerebral Infarction in Japanese Hemodialysis Patients: Miyazaki Dialysis Cohort Study (MID study).

Background/aims: Predictors including the preventive effects of antiplatelet and anticoagulant drugs on cerebral infarction (CI) events have not yet been clarified in dialysis patients. The aim of the present study was to examine the risk of CI and preventive effects of these drugs in Japanese hemodialysis patients.

Methods: Patients receiving maintenance hemodialysis (n=1,551, median age (interquartile range), 69.

Apoprotein B/Apoprotein A-1 Ratio and Mortality among Prevalent Dialysis Patients.

Background And Objectives: In dialysis patients, the associations between apoprotein profile and all-cause or cardiovascular disease (CVD)-related mortality are not well known. We, therefore, investigated whether apoprotein levels are associated with these events.

Design, Setting, Participants, & Measurements: We undertook a prospective observational cohort study of prevalent hemodialysis patients aged ≥18 years (n=1081), who were followed for 4 years (2011-2014).

Evaluation of a new bio-impedance spectroscopy device in healthy Japanese.

Background: The use of a new bio-impedance spectroscopy device (Body Composition Monitor, BCM) in the field of dialysis became possible in Japan. However, it is unknown whether the data obtained using this apparatus are indicative for Japanese dialysis patients.

Objective: To compare individual fluid status in healthy Japanese using the BCM device with the data obtained from healthy Caucasians.

Glycaemic control is a predictor of infection-related hospitalization on haemodialysis patients: Miyazaki Dialysis Cohort study (MID study).

Aim: Although infection is the second leading cause of death in maintenance haemodialysis patients, the effects of glycaemic control on infection in diabetic haemodialysis patients have not yet been examined in detail. We examined the relationship between diabetes or glycemic control and infection-related hospitalization (IRH) in haemodialysis patients.

Methods: Patients receiving maintenance haemodialysis (n = 1551, 493 diabetic patients) were enrolled in this prospective cohort study in December 2009 and followed-up for 3 years.

[Clinical characteristics of patients with IgA nephropathy and long-term survival after dialysis therapy].

Background And Objectives: Little is known about the treatment and clinical status of patients with biopsy-proven IgA nephropathy (IgAN) during long-term maintenance dialysis.

Methods: Fifty-two of 433 patients with IgAN who had favorable survival rates of 93.3% and 65.

Long-term survival of patients with IgA nephropathy after dialysis therapy.

Background/aims: How dialysis affects the survival of patients with biopsy-proven IgA nephropathy (IgAN) is not fully understood. The present long-term cohort study quantifies the survival rates and incidence of cardio-cerebrovascular diseases (CCVDs) among such patients in Japan.

Methods: Fifty-two of 433 patients with IgAN who had reached end-stage kidney disease underwent renal replacement therapy (RRT) between 1981 and 2010.

Allylation of alcohols and carboxylic acids with allyl acetate catalyzed by [Ir(cod)2](+)BF4- complex.

A facile method for the synthesis of allyl alkyl ethers from alcohols with allyl acetate was developed by the use of [Ir(cod)(2)](+)BF(4)(-) complex. For instance, the reaction of allyl acetate with n-octyl alcohol in the presence of a catalytic amount of [Ir(cod)(2)](+)BF(4)(-) complex afforded allyl octyl ether in quantitative yield. Allyl carboxylates were also prepared by the exchange reaction between carboxylic acids and allyl acetate in good yields.

An efficient direct alpha-alkylation of ketones with primary alcohols catalyzed by [Ir(cod)Cl]2/PPh3/KOH system without solvent.

alpha-Alkylation of ketones was successfully achieved by the reaction of ketones with alcohols catalyzed by iridium complexes in the presence of a small amount of base. For example, 2-octanone was allowed to react with butanol under the influence of [Ir(cod)Cl]2/PPh3/KOH to give 6-dodecanone in good yield. The reaction was found to proceed by using a 1:1 mixture of ketone and alcohol without use of any solvent.

Head-to-tail dimerization of acrylates catalyzed by iridium complexes.

Head-to-tail dimerizations of acrylates and vinyl ketone were successfully performed by the use of iridium complexes in good yields. An iridium hydride complex generated in situ from [IrCl(cod)]2 and alcohols in the presence of Na2CO3 and (MeO)3P was found to be an active species promoting the head-to-tail dimerization of acrylates. Thus, butyl acrylate afforded the corresponding head-to-tail dimer in 86% yield.