Publications by authors named "Hideto Egashira"
Background: There are many reports on the choice of treatment for and prognosis of left-sided obstructive colorectal cancer; however, few studies have focused on the prognostic factors of left-sided obstructive colorectal cancer. Therefore, we analyzed the prognostic factors using a post hoc analysis of a retrospective multicenter study in Japan.
Methods: A total of 301 patients were enrolled in this study to investigate the prognostic factors for relapse-free survival.
We herein report the definitive diagnosis of rectovaginal endometriosis in two cases. Case 1 involved a 46-year-old woman with abdominal pain and hematochezia. The diagnosis after the first and second examinations using lower gastrointestinal (GI) endoscopy was unclear.
View Article and Find Full Text PDFPancreatic pseudocyst and portal vein thrombosis are common conditions resulting from acute and chronic pancreatitis. However, pancreatic pseudocyst-portal vein fistula (PPVF) is a rare and life-threatening complication. In PPVF patients, drainage or operative therapy is necessary under certain conditions, including communication between the pseudocyst and pancreatic duct, pancreatic duct stricture, pancreatic duct stone, and infection that is difficult to control with antibiotics.
View Article and Find Full Text PDFA 72-year-old man who had been on continuous ambulatory peritoneal dialysis treatment for 10 years underwent cardiopulmonary bypass for aortic valve replacement due to aortic valve stenosis. After surgery, he experienced pancreatitis, and rupture of a splenic artery aneurysm. He went into cardiopulmonary arrest but was successfully treated by transcatheter arterial embolization (TAE) with cardiopulmonary resuscitation.
View Article and Find Full Text PDFBackground: Thoracic endovascular aortic repair of an aortoesophageal fistula is an effective emergency treatment for patients with T4-esophageal cancer, as it prevents sudden death, and is a bridge to surgery. However, the course of unresectable malignant aortoesophageal fistula treated with thoracic endovascular aortic repair alone is not well-known.
Case Presentation: We report a 67-year-old Japanese man with T4-esophageal cancer who experienced a chemoradiation-induced aortoesophageal fistula and was rescued with thoracic endovascular aortic repair.
A 69-year-old male patient presented with multiple lung nodules revealed by chest-computed tomography (CT) during a preoperative examination for an appendiceal tumor. The nodule diameters ranged from 2-10 mm without either pleural thickening or effusions. A fluorine-18-labeled fluorodeoxyglucose (F-FDG)-positron emission tomography (PET)/CT scan showed a high FDG uptake in the appendiceal tumor, but almost normal standardized uptake values in the bilateral lung nodules.
View Article and Find Full Text PDFAim: To assess the effects of a combination therapy with natriuretic and aquaretic drugs in cirrhotic ascites patients.
Methods: A two-center, randomized, open-label, prospective study was conducted. Japanese patients who met the criteria were randomized to trial group and the combination diuretic group (received 7.
Objective: The aim of this study was to assess the effect of branched-chain amino acid (BCAA) supplements on muscle strength and muscle mass in patients with liver cirrhosis.
Patients And Methods: We carried out a single-center, prospective study of adult cirrhotic patients receiving nutrition therapy at Shonan Kamakura General Hospital. A 28-day pretreatment observation period was followed by a 24-week treatment period.
Background/objective: Patients with left-sided malignant colorectal obstruction require emergency treatment. Emergency stoma surgery has traditionally been recommended, however many stomas became permanent, decreasing patient quality of life. Recently, self-expandable metallic stents (SEMS) and transanal decompression tubes (TDT) have become widely used decompression methods to avoid stoma surgery.
View Article and Find Full Text PDFAim: To assess the correlation between response to tolvaptan and treatment-related factors in liver cirrhosis patients.
Methods: This single-center retrospective study was carried out at Shonan Kamakura General Hospital in Kanagawa, Japan, between October 2013 and September 2015. Forty-three liver cirrhosis patients (mean age, 65.
Condyloma acuminatum of the anal canal, treated with endoscopic submucosal dissection.
World J Gastroenterol
February 2016
Condyloma acuminatum (CA) is a common sexually transmitted disease caused by human papilloma virus infection. Not all individuals develop persistent, progressive disease, but careful follow up is required with moderate-to-severe dysplasia to prevent progression to malignancy. Standard therapies include surgical treatments (trans-anal resection and trans-anal endoscopic microsurgery) and immunotherapeutic and topical methods (topical imiquimod); however, local recurrence remains a considerable problem.
View Article and Find Full Text PDFHere, we report a case of an amoebic liver abscess (ALA) successfully treated with endoscopic ultrasound (EUS)-guided liver abscess drainage (EUS-LAD). A 37-year-old male with a liver abscess was referred to our hospital due to disease progression despite receiving antibiotic therapy. Computed tomography showed an intrahepatic abscess extending into the hepatic subcapsular space.
View Article and Find Full Text PDF[A case of MALT lymphoma of the colon, stomach, and small intestine].
Nihon Shokakibyo Gakkai Zasshi
February 2015
Article Synopsis
- - An 85-year-old man was diagnosed with colon MALT lymphoma and initially treated by trying to eradicate Helicobacter pylori, which didn't work.
- - After 4 years of no treatment and stable condition, he was lost to follow-up and later developed new lymphoma lesions in the stomach and small intestine, 9 years after the initial diagnosis.
- - Genetic testing revealed a specific fusion gene linked to the lymphoma, indicating it had spread and suggested the need for careful monitoring of multiple lesions in MALT lymphoma cases.
Article Synopsis
- * Researchers reviewed data from 85 AIP patients and performed immunostaining on biopsy samples from 46 patients (14 with AIP and 32 with UC).
- * Results showed that while UC can occur with AIP, it is not solely a sign of IgG4-related disease; however, higher levels of IgG4-positive plasma cells in UC patients were linked to more severe disease activity.
Mixed acinar-endocrine carcinoma of the pancreas treated with S-1.
Clin J Gastroenterol
December 2013
Article Synopsis
- A 63-year-old man was diagnosed with acinar cell carcinoma of the pancreas, presenting with a large mass and multiple liver metastases.
- He underwent S-1 chemotherapy, which initially showed partial effectiveness, as indicated by decreased serum levels of CA19.9 and NSE.
- However, after 10 months, the tumor progressed, leading to liver failure and death 18 months later, with autopsy revealing a mixed acinar-endocrine carcinoma, suggesting the chemotherapy was more effective against the acinar component than the neuroendocrine differentiation.
Article Synopsis
- Autoimmune pancreatitis (AIP) lacks a specific diagnostic serological marker and is diagnosed using unique features from four different diagnostic criteria sets.
- A study compared these criteria among 85 AIP patients, finding that diagnosis rates were high: 87% with Japanese 2006, and 95% for Asian, ICDC, and Japanese 2011 criteria.
- The ICDC effectively differentiates between types 1 and 2 AIP with high sensitivity, but its complexity suggests that diagnostic criteria may need to be simplified and adapted for use in various countries.
Article Synopsis
- * Researchers measured serum IgG4 levels and examined tissue samples from 54 IPMN patients, finding elevated IgG4 levels in only 4% of them and significant IgG4-positive plasma cell infiltration in 17% of the cases.
- * The findings suggest that while IgG4-positive plasma cell infiltration can occur around IPMNs, it is rare and does not imply a strong link to AIP type 1
Article Synopsis
- The study aimed to understand the clinical characteristics of IgG4-related retroperitoneal fibrosis (RF) through specific diagnostic criteria involving serum IgG4 levels and tissue infiltration.* -
- Ten patients were analyzed, revealing a mean age of 70.1 years, with a predominance of associated diseases over initial symptoms related to RF, which included issues like back pain and lower extremity edema.* -
- Histological confirmation of the disease was achieved in most cases, and seven patients treated with steroids showed positive responses, highlighting the importance of recognizing the condition for accurate diagnosis and management.*
Article Synopsis
- * Results showed that VD type patients experienced more obstructive jaundice (87%) compared to D type patients (0%), while abdominal pain was more common in D type (24%) than in VD type (2%).
- * The findings suggest a new condition called "autoimmune dorsal pancreatitis," characterized by involvement only of the dorsal pancreas, with less frequent complications like obstructive jaundice and lower bile duct stenosis.
Article Synopsis
- The study aims to differentiate between immunoglobulin G (IgG) 4-related sclerosing cholangitis (IgG4-SC) and hilar cholangiocarcinoma (CC) due to the lack of previous research on the topic.
- A comparison of clinical, serological, imaging, and histological features revealed that patients with CC often present with more severe jaundice and higher serum levels of specific markers, while those with IgG4-SC show elevated IgG and IgG4 levels, along with pancreas enlargement.
- The findings suggest that an integrated diagnostic approach considering all these factors is crucial for accurately distinguishing between IgG4-SC and hilar CC.
Article Synopsis
- The study investigates the characteristics of pancreatic cancer patients who experience acute pancreatitis compared to other pancreatic cancer patients without pancreatitis and patients with acute pancreatitis without cancer.
- It involved a comparative analysis of 18 patients with both pancreatic cancer and acute pancreatitis, 300 patients with pancreatic cancer but no pancreatitis, and 141 patients with acute pancreatitis only.
- The findings suggest that in cases of acute pancreatitis, especially when the cause isn't clear, doctors should evaluate for potential pancreatic cancer, even if the pancreatitis is mild.
Article Synopsis
- Autoimmune pancreatitis (AIP) often leads to diabetes mellitus (DM), and this study aimed to assess how steroid therapy affects DM in AIP patients.
- In a study of 69 patients with AIP, 46% had DM, and after three months of steroid treatment, about 54% of these patients showed improvement in their glucose levels.
- The findings suggest that around 60% of DM cases related to AIP respond positively to steroids over time, indicating that significant DM in these patients may warrant steroid therapy. *
A 79-year-old man had a 3.5-year history of edema of the lower extremities of unknown etiology. Abdominal computed tomography showed a soft tissue mass around the abdominal aorta, and the biopsy revealed dense fibrosis with abundant infiltration of IgG4-positive plasma cells.
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