Publications by authors named "Hidetaka Yamanaka"
Article Synopsis
- - A 64-year-old man with a history of trauma and previous sinus surgery experienced recurrent orbitofrontal cholesterol granuloma, presenting symptoms like nasal congestion, loss of smell, and double vision.
- - Initial CT scans indicated a mass linked to chronic sinusitis, leading to the diagnosis of cholesterol granuloma after endoscopic surgery removed the cyst.
- - The lesion recurred after two months, requiring a Modified Lothrop (Draf III) procedure, which successfully prevented relapse over a five-year period, highlighting its effectiveness as a treatment option.
Bisphenol A induces Nrf2-dependent drug-metabolizing enzymes through nitrosylation of Keap1.
Drug Metab Pharmacokinet
August 2018
Bisphenol A (BPA) is an endocrine-disrupting chemical, and activates the aryl hydrocarbon receptor (AhR) and the estrogen receptor, leading to the induction of drug metabolizing enzymes. In this study, we found that BPA increased nitric oxide (NO) levels but not reactive oxygen species (ROS) levels in the human hepatoma cell line, Hep3B, and induced drug-metabolizing enzymes such as UDP-glucuronosyltransferase (UGT). Nuclear factor erythroid 2-related factor 2 (Nrf2) has been reported to be activated by ROS through inactivation of its regulating protein, Kelch-like ECH-associated protein (Keap1), and to be the key mediator of phase I and phase II drug metabolizing enzymes, and phase III drug transporters.
View Article and Find Full Text PDFWe report a patient who had rhinogenic intracranial complication with postoperative frontal sinus pyocele and inverted papilloma in the nasal cavity. A 72-year-old woman had undergone surgery for frontal sinusitis via external incision at another hospital 13 years previously. Left-sided hemiparesis appeared in the patient and gradually worsened.
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