Publications by authors named "Hidetaka Urya"
Article Synopsis
- The DNA damage response is crucial for keeping our genetic material stable and its disruption is often linked to cancer development.
- PPM1D acts as a key negative regulator of this response, and mutations in this gene have been found in various cancers, making it a potential target for new treatments.
- Using CRISPR/Cas9 screening, researchers identified SOD1 as a promising target for cells with PPM1D mutations, showing that these cells have higher levels of reactive oxygen species and struggle with oxidative stress, indicating a new cancer therapy approach.
