Publications by authors named "Hidenori Umetsu"
Recent studies have revealed the importance of cell membrane stability in normal cell function. Sphingomyelin phosphodiesterase acid-like 3b (SMPDL3b), a lipid modifying enzyme that converts sphingomyelin to ceramide in the cell membrane, is expressed in macrophages and regulates Toll-like receptor (TLR) 4 signaling by altering cell membrane fluidity. SMPDL3b is also expressed in human podocytes, which are involved in the pathogenesis of several glomerular diseases such as diabetic kidney disease, focal segmental glomerulosclerosis, and idiopathic nephrotic syndrome in children; however, the role of SMPDL3b in podocyte innate immunity is unclear.
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- TLR3 signaling is linked to chronic kidney diseases, influencing inflammatory responses in human podocytes, particularly through the cytokine IL-6.
- The study utilized poly IC to stimulate podocytes and measured the expression of inflammatory markers, revealing that TLR3 activation increases IL-6 alongside other chemokines.
- IL-6 was found to negatively regulate the expression of pro-inflammatory chemokines MCP-1 and CCL5, indicating its complex role in TLR3-mediated inflammation.
Introduction: Various viruses including a novel coronavirus (SARS-CoV-2) can infect the kidney. When viruses invade the glomeruli from the bloodstream, glomerular endothelial cells (GECs) initiate the innate immune reactions. We investigated the expression of interferon (IFN)-induced protein with tetratricopeptide repeats (IFIT) 1/2/3, antiviral molecules, in human GECs treated with a toll-like receptor (TLR) 3 agonist.
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