Publications by authors named "Hidenobu Shozawa"
Article Synopsis
- * Four patients experienced inappropriate secretion of antidiuretic hormone, while one had a brain lesion and all benefited from sodium channel blockers to reduce certain seizure types.
- * Immunotherapy was effective in four out of five patients, with no relapses reported over a two-year follow-up, highlighting the importance of quick diagnosis and treatment for those with similar symptoms.
Article Synopsis
- Diagnostic apraxia is a condition linked to corpus callosal disconnection, and while lesions in the corpus callosum have been noted in Neuromyelitis optica spectrum disorder (NMOSD), such cases are rare.
- A 48-year-old woman presented with symptoms including balance issues, slurred speech, and uncoordinated movements of her left hand while using her right, alongside other signs of callosal disconnection like left ear extinction and crossed optic ataxia.
- MRI scans revealed a "marbled pattern" in the corpus callosum, and after being diagnosed with NMOSD and treated with steroid pulse therapy, her symptoms improved.
Alzheimer disease (AD) is the most common type of dementia, and is currently incurable. The efficacy of existing treatments for AD such as acetylcholinesterase inhibitors is limited to symptom improvement. Research on disease-modifying therapies (DMTs) has conventionally focused on amelioration of CNS pathogenesis.
View Article and Find Full Text PDFBackground: Effects of dopaminergic medication on executive function in patients with Parkinson's disease (PD) are inconsistent.
Objective: We examined the effect of dopaminergic medication on executive function in 24 drug-naïve PD patients (de novo group) and in 21 PD patients on chronic dopaminergic medication (chronic medication group).
Methods: PD patients without dementia were included in this study.
Alzheimer's disease (AD) is a slowly progressive form of dementia, characterized by memory impairment and cognitive dysfunction. AD is mainly characterized by the deposition of amyloid β (Aβ) plaques and intracellular neurofibrillary tangles in the brain, along with neuronal degeneration and high levels of oxidative stress. Cilostazol (CSZ) was recently found to suppress the progression of cognitive decline in patients with stable AD receiving acetylcholinesterase inhibitors.
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