Publications by authors named "Hideki Ushiama"
While the urinary concentration ratio of 6beta-hydroxycortisol (6beta-HC) to cortisol (C) in 24-h urine samples is an established parameter for the induction of hepatic cytochrome P450 (CYP) 3A activity, it remains unclear whether it would be reduced in association with chronic liver damages. To clarify this issue we measured this parameter in 12 patients with chronic hepatitis, 15 patients with liver cirrhosis and 12 healthy subjects. Urinary 6beta-HC and C were assayed with high-performance liquid chromatography with ultraviolet absorption.
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- - The use of theophylline as a bronchodilator has decreased over the past 20 years, but it can still play a key role during emergency asthma attacks, often in combination with other medications.
- - Recent studies indicate theophylline may be beneficial for managing both stable and exacerbated asthma, though it has a low therapeutic index, meaning the effective dose is close to the toxic level.
- - Physicians must understand the pharmacokinetics of theophylline, especially for elderly patients, who may require dosage adjustments due to factors like reduced clearance and interactions with other medications; therapeutic drug monitoring is essential after starting treatment.
Objective: A 7-day triple therapy with lansoprazole, amoxicillin (INN, amoxicilline), and clarithromycin is widely used for eradication of Helicobacter pylori. Because clarithromycin is a potent inhibitor of cytochrome P450 (CYP) 3A, we investigated whether the standard triple therapy with clarithromycin would elicit clinically relevant CYP3A inhibition and alter CYP3A-mediated lansoprazole disposition in H pylori-positive patients.
Methods: Twenty H pylori-positive patients with peptic ulcer disease were randomly assigned to 2 groups: One group received 200 mg clarithromycin, 30 mg lansoprazole, and 750 mg amoxicillin at 8 am and 8 pm for 7 days; the other group received 400 mg clarithromycin, 30 mg lansoprazole, and 750 mg amoxicillin at 8 am and 8 pm for 7 days.