Insulin secretion and glucose utilization are impaired under general anesthesia with sevoflurane as well as isoflurane in a concentration-independent manner.

Purpose: The dose-dependent effects of sevoflurane and isoflurane anesthesia on glucose tolerance were compared in humans.

Methods: A prospective, randomized clinical study was conducted in 30 patients. The 30 patients were divided randomly into three sevoflurane anesthesia groups (0.