Publications by authors named "Hideki Minatogawa"
Background And Purpose: Radiation-induced lymphopenia (RIL) may be associated with a worse prognosis in pancreatic cancer. This study aimed to develop a normal tissue complication probability (NTCP) model to predict severe RIL in patients with pancreatic cancer undergoing concurrent chemoradiotherapy (CCRT).
Materials And Methods: We reviewed pancreatic cancer patients treated at our facility for model training and internal validation.
Article Synopsis
- This study examines the impact of adaptive radiotherapy (ART) on patients with locally advanced nasopharyngeal carcinoma treated with intensity-modulated radiotherapy (IMRT), comparing outcomes with a non-ART historical control group.
- Results indicated that while the ART group experienced higher rates of progression-free survival (PFS) and locoregional recurrence-free survival (LRFS), overall survival (OS) and distant metastasis-free survival (DMFS) were similar between both groups.
- The findings suggest that ART may enhance locoregional control, particularly in the primary tumor, highlighting its potential effectiveness in treatment despite differences in patient backgrounds.
The objective of this study was to determine the outcomes of radical radiotherapy for early glottic squamous cell carcinoma (EGSCC) with the policy of increasing the fraction size during radiotherapy when the overall treatment time (OTT) was expected to be prolonged. Patients diagnosed with clinical T1-2N0M0 EGSCC, who were treated with radical radiotherapy between 2008 and 2019 at Hokkaido University Hospital, were included. Patients received 66 Gy in 33 fractions for T1 disease and 70 Gy in 35 fractions for T2 disease as our standard regimen (usual group [UG]).
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- The study aimed to validate the Graded Prognostic Assessment for lung cancer (Lung-molGPA) in Japanese non-small cell lung cancer (NSCLC) patients with brain metastasis (BM) by analyzing factors affecting survival.
- A retrospective analysis of 294 NSCLC patients treated with radiotherapy revealed median overall survival (OS) times significantly varied based on GPA scores and treatment history, particularly noting the benefits of osimertinib in adenocarcinoma patients with gene mutations.
- Although survival varied across PD-L1 expression levels, the differences were not statistically significant, indicating that other factors might play a more critical role in survival outcomes for patients with BM.
Introduction: Sequential boost intensity-modulated radiotherapy (SQB-IMRT) uses two different planning CTs (pCTs) and treatment plans. SQB-IMRT is a form of adaptive radiotherapy that allows for responses to changes in the shape of the tumour and organs at risk (OAR). On the other hand, dose accumulation with the two plans can be difficult to evaluate.
View Article and Find Full Text PDFBackground: We investigated whether prophylactic percutaneous endoscopic gastrostomy (PEG) is used effectively for patients treated with definitive concurrent chemoradiotherapy (CCRT) and the predictors of the need for PEG.
Methods: 326 patients with laryngeal, oropharyngeal or hypopharyngeal cancers were retrospectively reviewed.
Results: The PEG tube use group had more favorable results than the total parenteral nutrition and nasogastric tube groups in terms of rate of serum albumin loss, incidence of severe fever and aspiration pneumonia, CCRT completion rate and hospitalization period.
Pharyngeal cancer patients treated with intensity-modulated proton therapy (IMPT) using a model-based approach were retrospectively reviewed, and acute toxicities were analyzed. From June 2016 to March 2019, 15 pharyngeal (7 naso-, 5 oro- and 3 hypo-pharyngeal) cancer patients received IMPT with robust optimization. Simulation plans for IMPT and intensity-modulated X-ray therapy (IMXT) were generated before treatment.
View Article and Find Full Text PDFPurpose: To investigate potential advantages of adaptive intensity-modulated proton beam therapy (A-IMPT) by comparing it to adaptive intensity-modulated X-ray therapy (A-IMXT) for nasopharyngeal carcinomas (NPC).
Methods: Ten patients with NPC treated with A-IMXT (step and shoot approach) and concomitant chemotherapy between 2014 and 2016 were selected. In the actual treatment, 46 Gy in 23 fractions (46Gy/23Fx.
Article Synopsis
- A study investigated the impact of a nutritional supplement (Prosure®) high in w-3 fatty acids on patients with oropharyngeal and hypopharyngeal cancer receiving chemoradiotherapy.
- Patients who received Prosure® showed a significantly smaller weight loss (7.3%) compared to those who didn't (10.3%) and a lower incidence of severe oral mucositis (24% vs 58%).
- While the completion rate of chemoradiotherapy was higher in the Prosure® group (77%) compared to the control (60%), the difference was not statistically significant.