Synopsis of recent research by authors named "Hideki Hosono"
- Hideki Hosono's recent research primarily focuses on the development and application of monoclonal antibodies targeting various receptors involved in cancer progression, notably epidermal growth factor receptors (EGFR and HER2), as well as podoplanin and TROP2, emphasizing their roles in tumor growth and differentiation.
- His studies include innovative methods for epitope mapping of monoclonal antibodies, such as the RIEDL insertion for epitope mapping (REMAP) method, to enhance the identification of mAb-binding sites, which is critical for targeted therapies in oncology.
- The findings from these studies indicate significant antitumor activities of various newly developed monoclonal antibodies in mouse xenograft models, showcasing their potential as therapeutic agents in treating cancers associated with receptor overexpression, alongside the need for sensitive detection methods for these biomarkers.
