Publications by authors named "Hidekazu Kohno"
WIF-1 is a negative regulator of the Wnt-signaling pathway that may have important implications for tumorigenesis. Microarray analysis of whole genome expression in mesothelioma tissue revealed down-regulation of 491 genes and up-regulation of 167 genes involved mainly in Jak-STAT signaling (8 genes), MAPK signaling (16 genes) and Wnt signaling (13 genes) pathways. Of these, WIF-1 gene was down-regulated in mesothelioma 72-fold compared to normal tissue.
View Article and Find Full Text PDFAims: The incidence of mesothelioma is increasing in Europe, Japan and other developing countries. There is difficulty in the accurate diagnosis of mesothelioma and its differentiation from lung adenocarcinoma. Mesothelioma shows a complex immunohistochemical profile.
View Article and Find Full Text PDF[A case of pulmonary malignant lymphoma with endobronchial involvement with repeated improvement or progress of atelectasis].
Nihon Kokyuki Gakkai Zasshi
December 2008
Article Synopsis
- A 68-year-old woman arrived at the emergency department with a dry cough and worsening shortness of breath, leading to a chest X-ray that revealed complete atelectasis of her right upper lobe.
- After receiving corticosteroids, her wheezing and atelectasis improved within 14 hours, but she later developed atelectasis in other lung regions over the following weeks.
- A bronchoscopic examination revealed severe stenosis in her right bronchus, and a biopsy confirmed the diagnosis of primary pulmonary malignant lymphoma, marking a rare case of endobronchial involvement.