Gingival enlargement improvement following medication change from amlodipine to benidipine and periodontal therapy.

The use of calcium channel blockers (CCBs) is associated with gingival enlargement, which adversely affects oral function, hygiene and aesthetics. Although CCB-induced gingival enlargement is a known adverse effect, it is rarely or never caused by some CCBs. In this paper, we report the case of a late 80's female patient with hypertension who experienced amlodipine-induced gingival enlargement.

Management of traumatic dental injury after periodontal surgery in patient with hereditary gingival fibromatosis: case report.

Traumatic Dental Injury (TDI) is often caused by a bruise from a sports-related incident or fall. In individuals with maxillary protrusion, the risk for TDI may be higher. We treated a patient with Hereditary Gingival Fibromatosis (HGF), a rare genetic disorder characterized by proliferative fibrous overgrowth of gingival tissue, who subsequently received a TDI after periodontal surgery.

Interleukin-1 receptor gene variants are associated with aggressive periodontitis in the Japanese.

Objective: Previous studies have indicated that type-1 and type-2 interleukin-1 (IL-1) receptors (IL-1R1 and IL-1R2) play important roles in periodontitis progression. We investigated the association between periodontitis and polymorphisms in the IL-1R1 and IL-1R2 genes (IL1R1 and IL1R2).

Design: We searched for genetic variants in IL1R1 and IL1R2 in 24 Japanese patients with aggressive periodontitis (AgP) and 24 periodontally healthy controls.

[Searches for the genes associated with periodontitis with gene polymorphisms].

Periodontitis is considered to be a common disease which onset and progression seems to be associated with genetic factors and many environmental factors, especially, the amount and composition of bacterial plaque. Previous studies have shown an association between periodontitis and polymorphisms in some genes, however, the critical loci for periodontal disease have not yet been identified. In the future, whole-genome association studies with periodontitis would suggest that the genetic susceptibility loci for periodontitis and provides important information for elucidation of the molecular mechanisms involved in the etiology of periodontal disease.

Association analysis between longevity in the Japanese population and polymorphic variants of genes involved in insulin and insulin-like growth factor 1 signaling pathways.

Recent studies have demonstrated a significant association between mutations in genes involved in the insulin/IGF1 signaling pathway and extension of the life span of model organisms. In this study which compared 122 Japanese semisupercentenarians (older than 105) with 122 healthy younger controls, we examined polymorphic variations of six genes which are involved in insulin/IGF1 signaling. These genes were FOXO1A, INSR, IRS1, PIK3CB, PIK3CG, and PPARGC1A.

Association analysis of the SHC1 gene locus with longevity in the Japanese population.

The SHC1 gene encodes a signaling and transforming protein that has been implicated in the aging process in worms and mammals. In this study we examined 230 Japanese centenarians and 180 healthy younger controls and looked at the SHC1 locus as a candidate region that may be associated with longevity. We identified 12 single nucleotide polymorphisms (SNPs) within a 10-kb region encompassing the entire SHC1 gene from the DNA of 30 centenarians and 24 healthy younger controls.