Publications by authors named "Hidefumi Sueoka"
Introduction: NK2 homeobox 1 (NKX2-1) encodes a transcription factor, NKX2-1, that is expressed in the thyroid gland, lung, and brain. Dual oxidase 2 (DUOX2) encodes an enzyme which generates hydrogen peroxide and is involved in the thyroid hormone synthesis. Cases of congenital hypothyroidism (CH) with dyshormonogenesis showing two or more genetic variants are increasingly reported.
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- In patients with chronic adrenal insufficiency, physical stress requires higher doses of glucocorticoids, but the effects of mental stress on treatment are less clear.
- A case study details a 17-year-old girl with septo-optic dysplasia who experienced worsening symptoms of nausea and stomach pain after her grandfather's death, even when receiving stress doses of hydrocortisone and glucagon.
- Her condition improved significantly after switching to continuous infusions of hydrocortisone and glucose, highlighting the importance of early glucocorticoid dosing during mental stress situations.