Publications by authors named "Hideaki Ishii"

This report presents the long-term (over 15 years) results of four Japanese patients who underwent total joint replacement for thumb carpometacarpal (CMC) joint arthritis. Four patients (mean age 60.5 years) underwent prosthesis replacement for thumb CMC joint arthritis with AVANTA(TM) (Small Bone Innovations, Morrisville, PA, USA) implants between 2001 and 2004, with a mean follow-up of 20 years and seven months.

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The abuse of prohibited peptide-based drugs with a broad spectrum of chemical characteristics poses a significant concern for the horseracing industry. Recently, there has been a notable increase in positive cases of small-peptide drugs reported in equine and canine sports. In addition to small peptides, large peptides (over 2 kDa) with structural diversity have also entered the market in increasing numbers as drugs for humans and livestock.

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Aim: Driving cessation is strongly associated with adverse health outcomes in older adults. Although numerous studies have focused on driving skill interventions for safe driving, the effects of interventions on car accidents remain unclear. We designed a randomized controlled trial to examine the effects of driving skill training on the prevention of car accidents among community-dwelling older adults using on-road training.

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[Purpose] This study aimed to clarify the association between phase angle (PhA) and the level of independence in daily living among institutionalized super older females requiring nursing care. [Participants and Methods] This three-facility cross-sectional study enrolled 173 nursing home residents (mean age 91.0 years, standard deviation 4.

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Article Synopsis
  • The study investigates osilodrostat, a drug for Cushing's disease, and its potential misuse in horse racing due to its anabolic properties, leading to its classification as a banned substance.
  • Four thoroughbred horses were given osilodrostat, and extensive screening identified 37 metabolites, with key findings including M1c (a mono-hydroxylated form) and osilodrostat glucuronide, which showed a long detection time in urine.
  • For effective doping control, both osilodrostat and M1c should be screened in horse urine samples, and only osilodrostat can be confirmed using a reference material.
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  • Osilodrostat, an anabolic agent developed for Cushing's disease, is banned in horses by major equestrian authorities due to its potential misuse in doping.
  • Studies established the elimination profiles of osilodrostat and its metabolite M1c in horse urine, using a validated method for accurate detection post-administration.
  • Findings indicate hydrolyzed osilodrostat can be detected for up to 72 hours, while both it and M1c can be found in urine samples for up to 2 weeks, leading to recommendations for monitoring both substances for effective doping control.
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Rationale: To uphold the integrity of horseracing and equestrian sports, it is critical for an equine doping control laboratory to develop a comprehensive screening method to cover a wide range of target substances at the required detection levels in equine urine.

Methods: The procedure involved the enzymatic hydrolysis of 3 mL urine samples followed by solid-phase extraction using HF Bond Elut C18 cartridge. The resulting extracts were then separated on a C18 reversed-phase column and analyzed using liquid chromatography/high-resolution mass spectrometry (LC/HRMS) in both electrospray ionization positive and negative modes in two separate injections.

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Residual deformity of the trochlea after fractures of the distal end of the humerus in children is well known and is referred to as fishtail deformity. Despite numerous reports on this entity, the reason for various types of fractures with the same results remains unknown. Fishtail deformities after non-displaced supracondylar fractures are very rare.

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Article Synopsis
  • Osilodrostat is an inhibitor used to treat Cushing's disease and is banned in horseracing due to its anabolic properties; this study marks the first metabolic analysis of osilodrostat in horses.
  • The researchers identified osilodrostat's potential metabolites using advanced mass spectrometry techniques on plasma samples collected before and after drug administration.
  • Results showed that the mono-hydroxylated form of osilodrostat was the main metabolite found in plasma, and both the drug and its metabolite remained detectable for up to two weeks, suggesting the need for thorough doping tests in equine sports.
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The primary aim of this systematic review was to examine the efficacy of driving interventions with regard to a reduction in motor vehicle crashes and improvements in driving skills among older people. The secondary aim was to identify the optimal type (on-road or off-road) and dosage (period, sessions, and duration) of driving interventions for improving driving skills in older people. We searched MEDLINE, EMBASE, PsycINFO, and Scopus of Systematic Reviews for papers published from their inception to December 1, 2020, as well as the reference lists of the included papers.

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  • - Vadadustat is a drug that helps treat anemia by stabilizing hypoxia-inducible factors, but its use is banned in horse racing and competitions.
  • - This study analyzed how long vadadustat can be detected in horse hair after administration, finding it detectable for up to six months but without its metabolites present.
  • - Results showed that the presence of vadadustat in hair decreases over time due to degradation, and it shifts along with hair growth, aiding in more accurate doping control.
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Background: Distal radius fractures (DRFs) are the most frequent first-ever osteoporotic fragility fractures. However, most patients are treated only for fractures and not for osteoporosis. Therefore, we investigated early osteoporosis intervention using zoledronic acid.

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  • Daprodustat is a medication used to stimulate red blood cell production and treat anemia, but its use in horses can lead to lifetime bans in equestrian sports due to regulatory guidelines.
  • A study administered daprodustat to thoroughbred mares and analyzed hair samples over six months to assess how long the drug and its metabolites could be detected compared to shorter detection times in plasma and urine.
  • The research found that daprodustat is primarily deposited in the hair near the scalp and spreads along the hair shaft over time, with analysis indicating that drug concentration in hair is influenced by factors like maximum plasma concentration and the drug's lipophilicity.
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Purpose: Conditioned pain modulation (CPM) is a measurement of the descending pain pathways that inhibit or facilitate afferent noxious stimuli. The reliability of CPM in older individuals with or without chronic musculoskeletal pain has not been sufficiently reported. This study aimed to examine the inter-session reliability of CPM in these cohorts and the factors in CPM reliability.

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Background: Frozen shoulder (FS) is speculated to have an inflammatory etiology. On angiography, abnormal angiogenesis is observed around the affected shoulder, suggesting a possible source of inflammation and pain. The effectiveness and safety of transarterial embolization (TAE) targeting abnormally proliferating blood vessels have been reported.

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Article Synopsis
  • A recent study explored the use of advanced liquid chromatography and mass spectrometry techniques to better identify drug metabolites in horses, focusing on the challenges posed by interfering substances.
  • The researchers enhanced the detection process by creating exclusion lists (ELs) to minimize interference, particularly when dealing with low concentrations of drug metabolites, using daprodustat as a model compound.
  • Their method successfully identified 21 metabolites of daprodustat in a single run, demonstrating the effectiveness of combining data-dependent acquisition (DDA) with exclusion lists for improving non-targeted analyses in doping control scenarios.
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Rationale: For the purpose of doping control, this is the first report of accurate quantification of four critical structural isomers of nicotine metabolites (trans-3'-hydroxycotinine, cis-3'-hydroxycotinine, 5'-hydroxycotinine, and N'-hydroxymethylnorcotinine) in equine plasma and urine for the establishment of their elimination profiles. Besides, the pharmacokinetic studies of trans-3'-hydroxycotinine and N'-hydroxymethylnorcotinine in equine plasma and urine are also presented for the first time.

Methods: The accurate quantification methods of the aforementioned four structural isomers in horse plasma and urine were successfully developed and validated using the solid-phase extractions followed by liquid chromatography/tandem mass spectrometry analysis.

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Article Synopsis
  • - Vadadustat is a banned substance in horse racing, and this study explores its metabolism in horses to improve doping control methods.
  • - Three thoroughbred mares were administered vadadustat, and comprehensive analyses were conducted to identify and quantify its metabolites in both plasma and urine.
  • - The findings revealed that vadadustat can be detected in equine plasma and urine for up to two weeks, aiding in the effective monitoring of its misuse in horses.
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IOX4, a hypoxia-inducible factor stabilizer, is classified as a banned substance for horses in both horse racing and equestrian sports. We recently reported the pharmacokinetic profiles of IOX4 in horse plasma and urine and also identified potential monitoring targets for the doping control purpose. In this study, a long-term longitudinal analysis of IOX4 in horse hair after a nasoesophageal administration of IOX4 (500 mg/day for 3 days) to three thoroughbred mares is presented for the first time for controlling the abuse/misuse of IOX4.

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The use of nicotine stimulants in horses is generally banned in horse racing and equestrian sports-accidental consumption of tobacco products is one of the possible causes of nicotine exposure in horses. The authors recently reported a comprehensive metabolic study of nicotine in equines, differentiating between nicotine exposure and sample contamination by means of a nicotine biomarker trans-3'-hydroxycotinine. To identify potential biomarkers for the differentiation of genuine nicotine administration and consumption of tobacco products, tobacco leaves (equivalent to 250 mg of nicotine) were nasoesophageally administered to three thoroughbred mares.

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Nicotine is classified as a stimulant, and its use is banned in horse racing and equestrian sports by the International Federation of Horseracing Authorities and the Fédération Équestre Internationale, respectively. Because nicotine is a major alkaloid of tobacco leaves, there is a potential risk that doping control samples may be contaminated by tobacco cigarettes or smoke during sample collection. In order to differentiate the genuine doping and sample contamination with tobacco leaves, it is necessary to monitor unique metabolites as biomarkers for nicotine administration and intake.

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Introduction: The aim of this study was to investigate whether the association between driving status and disability in older adults depends on social frailty.

Methods: This is a prospective study in a community setting. Participants were surveyed baseline conditions of social frailty and driving status (n = 4642, mean age: 71.

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IOX4 is a hypoxia-inducible factor prolyl hydroxylase (HIF-PHD) inhibitor, which was developed for the treatment of anemia by exerting hematopoietic effects. The administration of HIF-PHD inhibitors such as IOX4 to horses is strictly prohibited by the International Federation of Horseracing Authorities and the Fédération Équestre Internationale. To the best of our knowledge, this is the first comprehensive metabolic study of IOX4 in horse plasma and urine after a nasoesophageal administration of IOX4 (500 mg/day, 3 days).

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Objectives: To develop a questionnaire-based Active Mobility Index (AMI) to assess going-out behavior with physical and social activity among older adults, and to assess the criterion-related and predictive validity of the AMI.

Design: Prospective cohort study.

Setting And Participants: General community setting.

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Aim: Physical frailty is a critical health problem that can increase the risk of adverse health outcomes in older adults. Driving cessation has been associated with negative outcomes such as disability. However, the relationship between physical frailty and driving cessation remains unclear.

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