Publications by authors named "Hideaki Inazumi"
Adrenomedullin (AM) exerts strong pulmonary vasodilatory effects. These effects are mediated in part by nitric oxide. Plasma AM levels are increased in patients with pulmonary hypertension and correlate with disease severity and poor outcomes.
View Article and Find Full Text PDFReactivation of fetal cardiac genes, including those encoding atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP), is a key feature of pathological cardiac remodeling and heart failure. Intensive studies on the regulation of ANP and BNP have revealed the involvement of numerous transcriptional factors in the regulation of the fetal cardiac gene program. Among these, we identified that a transcriptional repressor, neuron-restrictive silencer factor (NRSF), also named repressor element-1-silencing transcription factor (REST), which was initially detected as a transcriptional repressor of neuron-specific genes in non-neuronal cells, plays a pivotal role in the transcriptional regulation of ANP, BNP and other fetal cardiac genes.
View Article and Find Full Text PDFArticle Synopsis
- Researchers found that NRSF (neuron restrictive silencer factor) helps maintain normal heart function by suppressing a fetal cardiac gene program that can lead to heart failure.
- They conducted studies using mice to analyze the role of NRSF and its effects on the gene Gα, which was linked to worsening cardiac function when overexpressed.
- The study concluded that targeting Gα might provide new therapeutic options for treating heart failure by improving calcium handling in heart cells.
Article Synopsis
- The 84th Annual Meeting of the Japanese Circulation Society was held online for the first time due to COVID-19 from July 27 to August 2, 2020, under the theme "Change Practice!"
- The event attracted over 16,800 registered attendees, significantly surpassing expectations, with many sessions receiving more views than typical in-person meetings.
- The success of this virtual format highlighted the effectiveness of online information sharing, suggesting a permanent shift in how academic gatherings are conducted in the future.
B-type natriuretic peptide (BNP) is a cardiac hormone widely used as a biomarker for heart failure. Here, we present the first report of extremely high levels of immunoreactive BNP caused by formation of macro-proBNP. A 70-year-old woman with left ventricular hypertrophy and normal systolic function presented with extremely high plasma levels of BNP (35,374pg/ml) and N-terminal proBNP (NT-proBNP; 30,600pg/ml).
View Article and Find Full Text PDFBackground: Recent studies have shown that plasma levels of the biologically inactive prohormone for brain natriuretic peptide (proBNP) are increased in patients with heart failure. This can contribute to a reduction in the effectiveness of circulating BNP and exacerbate heart failure progression. The precise mechanisms governing the increase in proBNP remain unclear, however.
View Article and Find Full Text PDFBackground: The long-term prognostic significance of in-hospital worsening renal function (WRF) during treatment of acute cardiac decompensation (ACD) remains controversial.
Methods: We analyzed data from 100 patients (mean age=75 years; 53% men) presenting with ACD, in whom the serum cystatin C (Cys-C) concentration was measured upon admission to the hospital and 4 days later. We examined the relationship between changes in Cys-C and primary study endpoint of risk of death and re-hospitalization for management of ACD, up to 180 days, searched for predictors by multiple variable analysis and calculated the hazard ratios (HR) and 95% confidence intervals (CI).