Investigation of Y chromosome microdeletions in algerian children with hypospadias.

Background: Hypospadias is a congenital condition where the urethral opening is located on the underside of the penis instead of at the tip. The Y chromosome, particularly the Azoospermia Factor (AZF) loci, plays a crucial role in male sexual development. Microdeletions in this region have been implicated in male infertility and hypothesized to contribute to congenital malformations like hypospadias.

Potential risk factors for hypospadias and negative correlation with DICER1 (rs3742330) A>G variant in Algerian population: A case-control study.

Background: Hypospadias continues to be a prevalent congenital anomaly affecting the male external genitalia, characterized by an unclear origin and complex treatment approaches. This study aimed to investigate the risk factors associated with hypospadias and explore its genetic link with the DICER1 rs3742330 variant.

Methods: The study involved two groups: 105 male children with hypospadias and 111 healthy male children as matched controls.

The interscrotal approach to inguinoscrotal pathologies.

Objective: To determine the efficiency of the interscrotal approach to inguinoscrotal pathologies.

Patients And Methods: We report the use of the interscrotal approach in 21 boys, from September 2012 to November 2013, operated using an interscrotal access through a vertical incision on the median raphe.

Results: The approach was used for bilateral inguinal hernia (48%), bilateral ectopic testis (19%), torsion of the spermatic cord (19%), testicular biopsy (10%) and webbing of the penis (5%).