Publications by authors named "Hibiki Nakamura"
Anionic boron clusters, such as [BX] (X = Cl, Br, I), have attracted attention in pharmaceuticals due to their unique superchaotropic properties. In particular, [BBr] () has demonstrated strong interactions with biomolecules, facilitating cargo translocation across plasma membranes. In this study, we investigated the effect of covalently attaching chlorinated dodecaborate moiety [BClO-] to 6-carboxyfluorescein (6-FAM) () via a PEG3 linker to form conjugate ().
View Article and Find Full Text PDFArticle Synopsis
- This study explored the effectiveness of an inertial measurement unit for analyzing gait differences between frail and robust older adults.
- Six participants in their 80s were evaluated based on established health criteria, measuring factors like sole clearance and stability shifts during walking.
- Results showed that frail participants had lower sole clearance and less center of mass shift, highlighting potential applications for rehabilitation programs and the design of supportive walking equipment.
OSW-1, a steroidal saponin isolated from the bulbs of Ornithogalum saundersiae, is a promising compound for an anticancer drug; however, its cytotoxic mechanisms have not been fully elucidated. Therefore, we analyzed the stress responses triggered by OSW-1 in the mouse neuroblastoma cell line Neuro2a by comparing it with brefeldin A (BFA), a Golgi apparatus-disrupting reagent. Among the Golgi stress sensors TFE3/TFEB and CREB3, OSW-1 induced dephosphorylation of TFE3/TFEB but not cleavage of CREB3, and induction of the ER stress-inducible genes GADD153 and GADD34 was slight.
View Article and Find Full Text PDF