Publications by authors named "Hibiki Kadoguchi"
Commensal microbes in animals have a profound impact on tissue homeostasis, stress resistance, and ageing. We previously showed in Drosophila melanogaster that Acetobacter persici is a member of the gut microbiota that promotes ageing and shortens fly lifespan. However, the molecular mechanism by which this specific bacterial species changes lifespan and physiology remains unclear.
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- An early inflammatory response during the development of Drosophila impacts long-term health, increasing adult starvation resistance but decreasing lifespan.
- Activation of the immune pathway in larvae causes noticeable effects, with lifespan shortening linked to Imd activation in the gut while starvation resistance relates to neuronal changes.
- The study highlights how early immune responses lead to lasting changes in gut microbiota, resulting in chronic inflammation and a reduced lifespan in adult flies.