Fibroblast growth factor receptor 2 gene () rs2981582T/C polymorphism and susceptibility to breast cancer in Saudi women.

Fibroblast growth factor receptor 2 is a protein encoded by gene and plays an important role in cellular growth. This study was conducted to investigate a potential association of rs2981582 with breast cancer. DNA was obtained from 137 Formalin-fixed, paraffin-embedded tumors and 98 normal breast tissue samples.

Murine Double Minute 2 Gene () rs937283A/G variant significantly increases the susceptibility to breast cancer in Saudi Women.

Breast cancer is predominant causes of mortality in women worldwide. Genetic polymorphisms have a significant role in breast cancer aetiology. and its inhibitor the murine double minute ) genes encode proteins that have crucial functions in the DNA damage response.

Estrogen Receptor 1 Gene (ESR1) rs2234693 Polymorphism and Breast Cancer Risk in Saudi Women.

Objective: The present study aimed to determine the role of ESR1 gene rs2234693 T/C polymorphism (PvuII) in the susceptibility to breast cancer and to assess the association of this polymorphism within presence or absence of estrogen, progesterone receptors, human epidermal growth factor receptor 2 (HER2) and with premenopausal and postmenopausal age in Saudi women.

Methods: The study was a retrospective case-control study. In this study, 137 breast cancer and 98 normal breast paraffin embedded tissues were included.