Microbiota composition effect on immunotherapy outcomes in colorectal cancer patients: A systematic review.

Background: Immune checkpoint inhibitors (ICIs) have emerged as an effective treatment for colorectal cancer (CRC). Studies indicate that the composition of gut microbiota could potentially serve as a biomarker for predicting the clinical effectiveness of immune checkpoint inhibitors.

Methods: Following PRISMA guidelines, the review was conducted after registering the protocol with PROSPERO.

Immunogenic characterization of AlPO adsorbed Td vaccine and liposome-mediated Td vaccine.

Purpose: The purpose of this study was to compare the antigenic potency and stability of tetanus and diphtheria (Td) vaccines when combined with aluminum phosphate (AlPO) and liposome adjuvants.

Materials And Methods: and analyses were conducted using the single radial immunodiffusion method and sodium dodecyl sulfate-polyacrylamide gel electrophoresis. The Td vaccines were prepared with AlPO adsorption and liposome-mediated delivery, and protein antigens were characterized using these methods.