Web-based and machine learning approaches for identification of patient-reported outcomes in inflammatory bowel disease.

Background: Messages from an Internet forum are raw material that emerges in a natural setting (i.e., non-induced by a research situation).

PPIDomainMiner: Inferring domain-domain interactions from multiple sources of protein-protein interactions.

Many biological processes are mediated by protein-protein interactions (PPIs). Because protein domains are the building blocks of proteins, PPIs likely rely on domain-domain interactions (DDIs). Several attempts exist to infer DDIs from PPI networks but the produced datasets are heterogeneous and sometimes not accessible, while the PPI interactome data keeps growing.