Publications by authors named "Hiago Murilo Melo"
Article Synopsis
- * Individuals with epilepsy face heightened risks for various heart-related problems, including arrhythmias, heart attacks, and even sudden death, largely due to a mix of traditional risk factors, genetic issues, and effects of medications.
- * The text emphasizes the need for better cardiac risk assessments in epilepsy patients, discussing echocardiographic findings and proposing future research and risk stratification models to tackle these concerns.
Article Synopsis
- The study evaluated the effectiveness of a machine learning algorithm for detecting focal epileptic seizures using heart rate variability data, with previous success seen in a Danish cohort.
- A total of 34 patients were analyzed, revealing the algorithm's ability to detect 84.8% of seizures, with high sensitivity for generalized tonic-clonic seizures at 96.2%.
- Results suggest this algorithm could be reliably used for real-time seizure detection in diverse patient populations, potentially integrating into wearable technology for epilepsy management.
Article Synopsis
- The study focuses on the GCS-Pupil score (GCS-P) as a tool to predict hospital mortality in Brazilian patients with severe traumatic brain injury (TBI), comparing its effectiveness to a model that includes additional clinical and radiological factors.
- Data from 1,066 patients were analyzed, revealing an overall hospital mortality rate of 32.8%, with the GCS-P score showing an accuracy (AUROC) of 0.73, compared to 0.80 for the more comprehensive model.
- The results indicate that the GCS-P can be used to predict hospital mortality in severe TBI cases, but further research is needed to assess its effectiveness for long-term outcomes in TBI patients
Article Synopsis
- The study aimed to assess cognitive performance one year after hospital discharge in patients with severe traumatic brain injury who had favorable outcomes.
- Out of 163 patients, 73 showed favorable outcomes based on the Glasgow Outcome Scale, but only 28 completed cognitive evaluations, which were then compared to healthy controls.
- Results indicated that many patients experienced significant cognitive deficits, especially in language and verbal memory, despite being categorized with favorable outcomes, with factors like longer hospital stays, older age, and lower education correlating with poorer performance.
Background: People with epilepsy (PWE) are at increased risk for premature death due to many factors. Sudden unexpected death in epilepsy (SUDEP) is among the most important causes of death in these individuals and possibly, sudden cardiac death (SCD) in epilepsy is also as important. The possibility of concurrent derangement in electrical and mechanical cardiac function, which could be a marker of early cardiac involvement in PWE, has not been investigated in that population.
View Article and Find Full Text PDFThis study aimed to compare heart rate variability (HRV) in patients with drug-resistant mesial temporal lobe epilepsy (MTLE) with healthy controls and to analyze their clinical and sociodemographic variables predictive for HRV. Thirty-nine consecutive patients with drug-resistant MTLE were included in the study. The control group included twenty-seven healthy participants matched by age and gender.
View Article and Find Full Text PDFMental fatigue alters cognitive performance and autonomic regulation. The neurovisceral model proposes that forebrain structures associated to cognitive control abilities influences heart rate variability. Parasympathetic mediated heart rate variability indices reduction during mental fatigue experience is well-described in previous studies, but the contribution of heart-brain axis to cardiac autonomic adaptation remains unknown.
View Article and Find Full Text PDFThe ERK phosphorylation levels in the amygdala predict anxiety symptoms in humans and MEK/ERK inhibition dissociates innate and learned defensive behaviors in rats.
Mol Psychiatry
December 2021
Article Synopsis
- The study found a negative association between the phosphorylation of ERK1,2 in the amygdala and anxiety symptoms in patients with drug-resistant epilepsy.
- In rats, lower levels of P-ERK1,2 in the amygdala correlated with increased anxiety-related behavior but showed a positive correlation with freezing during fear conditioning.
- The results indicate that ERK1/2 in the basolateral amygdala is necessary for learned defensive behaviors but does not affect innate anxiety responses, highlighting different mechanisms for these two types of behaviors.
Article Synopsis
- The study aimed to adapt the Faux Pas Recognition Test (FPRT) into Brazilian Portuguese and assess its effectiveness in evaluating Theory of Mind impairment in neuropsychiatric disorders.
- A multicentric study involved 153 healthy participants and used various psychometric analyses, including regression and factor analysis, to understand the relationship between FPRT scores and factors like age and education.
- The results indicated good internal consistency of the FPRT, with a positive correlation between test scores and education/social class, making it suitable for diverse educational contexts in Brazil.
Autonomic dysfunction in epilepsy is well-described. Heart rate variability (HRV) is a useful method to evaluate autonomic cardiac tone. Cardiac dysfunction may be involved in sudden unexpected death in epilepsy (SUDEP).
View Article and Find Full Text PDFThe central autonomic network, which is connected to the limbic system structures including the amygdala (AMY) and anterior hippocampus (aHIP), regulates the sympathetic and parasympathetic modulation of visceromotor, neuroendocrine, pain, and behavior manifestations during stress responses. Heart rate variability (HRV) is useful to estimate the cardiac autonomic tone. The levels of phosphorylation on the Ser831 and Ser845 sites of the GluA1 subunit of the AMPAr (P-GluA1-Ser845 and P-GluA1-Ser831) are useful markers of synaptic plasticity.
View Article and Find Full Text PDFInterictal dysphoric disorder (IDD) is a poorly understood psychiatric disorder of epilepsy patients. Interictal dysphoric disorder is characterized by depressive, somatoform, and affective symptoms observed in up to 5.9% of drug-resistant mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS).
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to find out how different factors, like age, education, and medication, affect cognitive performance in Brazilian patients with pharmacoresistant mesial temporal lobe epilepsy (MTLE).
- It involved 93 patients and looked at various variables through regression analysis to see which ones predicted scores on 24 cognitive tests.
- Results showed that higher education was the strongest positive predictor for cognitive performance, while left side lesions, longer disease duration, and certain medications had negative impacts on cognitive scores, explaining up to 44% of variation in the test results.
Early Alpha Reactivity is Associated with Long-Term Mental Fatigue Behavioral Impairments.
Appl Psychophysiol Biofeedback
March 2021
The quantitative analysis of electroencephalogram (qEEG) is a suitable tool for mental fatigue (MF) assessment. Here, we evaluated the effects of MF on behavioral performance and alpha power spectral density (PSD) and the association between early alpha PSD reactivity and long-term behavioral MF impairments. Nineteen right-handed adults (21.
View Article and Find Full Text PDFExcessive mental workload represent a critical risk factor for workplace accidents. Heart rate variability (HRV) is a non-invasive low cost electrophysiological autonomic biomarker related to emotional and cognitive regulation. Several studies report that mental overload impairs parasympathetic-mediated HRV indices (e.
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