Impact of blunt chest trauma on outcome after traumatic brain injury- a matched-pair analysis of the TraumaRegister DGU®.

Background: Traumatic brain injury (TBI) is associated with high rates of long-term disability and mortality. Our aim was to investigate the effects of thoracic trauma on the in-hospital course and outcome of patients with TBI.

Methods: We performed a matched pair analysis of the multicenter trauma database TraumaRegisterDGU® (TR-DGU) in the 5-year period from 2012 to 2016.

Early perfusion computerized tomography imaging as a radiographic surrogate for delayed cerebral ischemia and functional outcome after subarachnoid hemorrhage.

Background And Purpose: To date, there is no immediate radiographic surrogate to quantify primary cerebral injury to identify patients at risk for delayed cerebral ischemia and poor clinical outcome after aneurysmal subarachnoid hemorrhage. Therefore, we investigated the relation of early cerebral perfusion-computerized tomography and clot volume with radiological events of delayed cerebral ischemia and clinical outcome in patients with aneurysmal subarachnoid hemorrhage.

Methods: Data from 2 cohorts of patients (51 in main, 28 patients in control cohort) with aneurysmal subarachnoid hemorrhage, receiving computerized tomography and perfusion-computerized tomography scanning <12 hours after ictus, were included.

Local delivery of nimodipine by prolonged-release microparticles-feasibility, effectiveness and dose-finding in experimental subarachnoid hemorrhage.

Background And Purpose: To investigate the effect of locally applied nimodipine prolonged-release microparticles on angiographic vasospasm and secondary brain injury after experimental subarachnoid hemorrhage (SAH).

Methods: 70 male Wistar rats were categorized into three groups: 1) sham operated animals (control), 2) animals with SAH only (control) and the 3) treatment group. SAH was induced using the double hemorrhage model.

Early CT perfusion measurement after aneurysmal subarachnoid hemorrhage: a screening method to predict outcome?

Objective: The goal of the present study is to analyze the predictive impact of early CT-based perfusion measurement (CTP) on clinical outcome in patients suffering from aneurysmal SAH.

Methods: Fifteen patients with aneurysmal SAH received an early CTP measurement that was performed within the first 6 h after initial bleeding. According to a specific CTP protocol, mean transit time (MTT) and time to peak (TTP) were calculated bihemispherically and correlated with the clinical initial status according to the WFNS grade as well as with the Glasgow Outcome Scale (GOS) at the time of discharge.

Coiling of a carotid cavernous sinus fistula via microsurgical venotomy: recommendation of a combined neurosurgical and endovascular approach.

Introduction: Endovascular treatment of a carotid cavernous fistula (CCF) via a transvenous approach is standard but, in rare cases, the standard approach is not feasible due to vessel occlusion or anomalies. In such cases it remains a challenge to find an alternative route for complete treatment.

Clinical Presentation: A 42-year-old patient presented with a symptomatic CCF (Barrow type C).

Intraoperative Doppler and Duplex sonography in cerebral aneurysm surgery.

Purpose: The aim of open surgery of cerebral aneurysms is to minimise the risk of infarction due to poor position of a clip while still securing the aneurysm from rebleeding. Whilst digital subtraction angiography (DSA) remains the gold standard for precise evaluation of the result, its invasiveness, risk of thromboembolic infarction, availability and time-consumption pose a significant limitation, and overall it is rarely used. The goal of the present study was to analyse the feasibility of intraoperative B-mode Duplex ultrasound in combination with Doppler sonography (DDS) to evaluate this issue.

A cylindrical extracranial cranial base neurinoma of the hypoglossal nerve: a rare tumor with a rare localization: case report.

Objective: Neurinomas of the hypoglossal nerve are very rare. They are mostly located intracranially or combined intra- and extracranially, resulting in the so-called dumbbell shape. The isolated extracranial localization of the neurinoma of the hypoglossal nerve adjacent to the cranial base as described in this case report is extremely rare.