Expression of FOXO1 is associated with GATA3 and Annexin-1 and predicts disease-free survival in breast cancer.

Purpose: To determine the prognostic value of FOXO1, GATA3 and Annexin-1 expression in breast cancer.

Methods: Tissue microarray and individual paraffin tissue slides from 131 patients were used for the study. The association of FOXO1, GATA3 and Annexin-1 expression with clinicopathological features of breast cancer and disease outcome was examined in retrospective samples.

Clinical significance of Akt and HER2/neu overexpression in African-American and Latina women with breast cancer.

Introduction: Breast cancer patients with HER2/neu overexpression have poor outcomes with a decrease in disease-free survival (DFS) and overall survival. The biology of HER2/neu overexpression in breast tumors in African-American and Latina women is poorly understood. The purpose of this study is to understand the clinical significance of activated Akt (phospho-Akt or pAkt) expression in breast tumors from African-American and Latina patients with corresponding tissue HER2/neu overexpression.

Multiglandular parathyroid carcinoma: a case report and brief review.

A 53-year-old man with no past medical history was admitted with complaints of hematuria, flank and abdominal pain of one week duration. He also complained of an enlarging new neck mass one month before presentation. The laboratory assessment showed a calcium level of 17.

Natural history of multifocal solitary fibrous tumors of the pleura: a 25-year follow-up report.

We report this case with "multifocal solitary fibrous tumors of the pleura," which recurred at different sites in the left pleura at different time intervals over a span of 25 years, finally exhibiting features of malignant transformation. This patient was first seen in 1978, when she was 58 years of age, for episodic attacks of hypoglycemia and a mass occupying the entire left hemithorax. The operative findings and histologic appearance were that of a solitary fibrous tumor.

Primary hyperparathyroidism secondary to simultaneous bilateral parathyroid carcinoma.

Parathyroid carcinoma is a rare malignancy, and experience with its management is limited. It is generally accepted that surgery is the treatment of choice, and the initial operative intervention might represent the only chance for long-term success. At the time of surgery, a high index of suspicion for carcinoma is vital to performing the appropriate surgical procedures, because frozen-section diagnosis of parathyroid carcinoma is notoriously unreliable.