Solanum pan-genetics reveals paralogues as contingencies in crop engineering.

Pan-genomics and genome-editing technologies are revolutionizing breeding of global crops. A transformative opportunity lies in exchanging genotype-to-phenotype knowledge between major crops (that is, those cultivated globally) and indigenous crops (that is, those locally cultivated within a circumscribed area) to enhance our food system. However, species-specific genetic variants and their interactions with desirable natural or engineered mutations pose barriers to achieving predictable phenotypic effects, even between related crops.