Anti-angiogenic activity of para-coumaric acid methyl ester on HUVECs in vitro and zebrafish in vivo.

Background: Para-coumaric acid methyl ester (pCAME) is one of the bioactive components of Costus speciosus (Koen) Sm. (Zingiberaceae). This plant is traditionally used in Asia to treat catarrhal fevers, worms, dyspepsia, and skin diseases.

Three-coordinate iron(IV) bisimido complexes with aminocarbene ligation: synthesis, structure, and reactivity.

High-valent iron imido species are implicated as reactive intermediates in many iron-catalyzed transformations. However, isolable complexes of this type are rare, and their reactivity is poorly understood. Herein, we report the synthesis, characterization, and reactivity studies on novel three-coordinate iron(IV) bisimido complexes with aminocarbene ligation.

(Aminocarbene)(divinyltetramethyldisiloxane)iron(0) compounds: a class of low-coordinate iron(0) reagents.

The combined use of aminocarbene and divinyltetramethyldisiloxane (dvtms) as supporting ligands enables the access of unprecedented low-coordinate iron(0) alkene compounds [L(n)Fe(η(2):η(2)-dvtms)] (L=N-heterocyclic carbene (NHC) or cyclic (alkyl)(amino)carbene (CAAC), n=1 or 2) from the reactions of FeCl2 with alkali-metal reducing agents, free aminocarbene ligands, and dvtms. The iron(0) species deliver their {L(n)Fe(0)} fragments to perform redox reactions with Ph2SiH2, S8, Se, and DippN3, furnishing novel aminocarbene-supported iron(IV) silylene, all-ferrous iron-sulfur/selenium cubanes, and bis(imido)iron(IV) compounds. These conversions demonstrate the potential synthetic utility of the carbene-supported iron(0) complexes as a valuable class of low-coordinate iron(0) reagents.