Preparation and cell imaging of a nido-carborane fluorescent complex based on multi-component polymerization.

The biocompatibility of carborane was a difficult problem that had drawn a lot of study interest. Using multi-ion inlay binding, water-soluble polymers were created by encapsulating nido-carborane in diazaspirodecaniums such as para-poly-nido-carboanylazaspirodecanium [5,4] (p-PNC54), para-poly-nido-carboanylazaspirodecanium [6,5] (p-PNC65), meta-poly-nido-carboanylazaspirodecanium [5,4] (m-PNC54), and meta-poly-nido-carboanylazaspirodecanium [6,5] (m-PNC65). First, the active control 5-fluorouracil demonstrated strong activity against HeLa and HCT-116 cells but minimal cytotoxicity at 19.

Magnetic self-assembled label-free electrochemical biosensor based on FeO/α-FeO heterogeneous nanosheets for the detection of Tau proteins.

A type of electrochemical biosensors based on magnetic FeO/α-FeO heterogeneous nanosheets was constructed to detect Tau proteins for early diagnosis and intervention therapy of Alzheimer's disease (AD). Firstly, FeO/α-FeO heterogeneous nanosheets were fabricated as the substrate to realize magnetic self-assembly and magnetic separation to improve current response, and FeO/α-FeO@Au-Apt/ssDNA/MCH biosensors were successfully constructed through the reduction process of chloroauric acid, the immobilizations of aptamer (Apt) and ssDNA, and the intercept process of 6-Mercapto-1-hexanol (MCH); the construction process of the electrochemical biosensor was monitored using Cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS), and the factors affecting the current response of this sensor (concentration of FeO/α-FeO@Au and Apt/ssDNA, incubation temperature and time of Tau) were explored and optimized using differential pulse voltammetry (DPV). Analyzing the performance of this sensor under optimal conditions, the linear range was finally obtained to be 0.

Nucleic acid aptasensor with magnetically induced self-assembly for the detection of EpCAM glycoprotein.

A "turn-on" aptasensor for label-free and cell-free EpCAM detection was constructed by employing magnetic α-FeO/FeO@Au nanocomposites as a matrix for signal amplification and double-stranded complex (SH-DNA/Apt probes) immobilization through Au-S binding. α-FeO/FeO@Au could be efficiently assembled into uniform and stable self-assembly films via magnetic-induced self-assembly technique on a magnetic glassy carbon electrode (MGCE). The effectiveness of the platform for EpCAM detection was confirmed through differential pulse voltammetry (DPV).

Fabrication of magnetic-FeO/FeOheterostructure nanorods via the urea hydrolysis-calcination process and their biocompatibility with LOand HepGcells.

-FeOOH nanorods were prepared via the urea hydrolysis process with the average length of 289.1 nm and average diameter of 61.2 nm, while magnetic-FeO/FeOheterostructure nanorods were prepared via the urea calcination process with-FeOOH nanorods as precursor, and the optimum conditions were the calcination temperature of 400 °C, the calcination time of 2 h, the-FeOOH/urea mass ratio of 1:6.

Improved biopharmaceutical performance of antipsychotic drug using lipid nanoparticles via intraperitoneal route.

This study aims to develop, characterize, and examine olanzapine-loaded solid lipid nanocarriers (OLAN-SLNs) for effective brain delivery. OLAN has poor water solubility and low penetration through blood-brain barrier (BBB). Herein, OLAN-SLNs were fabricated using high-pressure homogenization (HPH) method followed by their investigation for particle properties.

Label-free electrochemical aptasensor based on magnetic α-FeO/FeO heterogeneous hollow nanorods for the detection of cancer antigen 125.

A label-free electrochemical aptasensor based on magnetic α-FeO/FeO heterogeneous hollow nanorods was developed for the detection of cancer antigen 125 (CA125). Magnetic α-FeO/FeO heterogeneous hollow nanorods were successfully prepared by the hydrolysis-calcination method, functionalized with polyethyleneimine (PEI), and modified with HAuCl to form magnetic α-FeO/FeO-Au nanocomposites with a layer of 5 nm gold nanoparticles (Au NPs) on the surface. The magnetic α-FeO/FeO-Au nanocomposites were used to fix the DNA-aptamer probe to amplify the current signal.

Diverse changes in myelin protein expression in rat brain after perinatal methadone exposure.

The national incidence of neonatal abstinence syndrome has dramatically increased over the last decade due to an increase in antenatal opioid exposure. Recent human and animal studies suggest that antenatal opioid exposure impacts the developing brain. The purpose of this study is to evaluate the effects of perinatal methadone exposure on myelination in multiple regions in the developing rat brain.

Association of serum neuron-specific enolase and bilirubin levels with cerebral dysfunction and prognosis in large-artery atherosclerotic strokes.

Purpose: To explore the association of serum neuron-specific enolase (NSE) and bilirubin levels with cerebral dysfunction in the prognosis of large-artery atherosclerotic (LAA) stroke cases.

Methods: This study included 73 patients who suffered from LAA stroke and were divided into experimental group (n = 41) that had an increased serum NSE and bilirubin level, and control group (n = 32). At day 1, 7, and 14, the National Institutes of Health Stroke Scale (NIHSS) score, serum NSE, and bilirubin levels were measured.