Effect of aggregating agents and their inhibitors on the mean platelet shape.

The ;swirling' seen when platelet-rich plasma is stirred is caused by the average asymmetry of the platelets and a technique for recording the swirling is reported. After the addition of adenosine diphosphate, 5-hydroxytryptamine, thrombin, and collagen, platelets become rounded and more symmetrical immediately before they become sticky. Monoiodo-acetate and adenosine prevent both the change in shape and sticking whereas E.

AMINO ACIDS: INCORPORATION INTO ALPHA- AND BETA-CHAINS OF HEMOGLOBIN BY NORMAL AND THALASSEMIC RETICULOCYTES.

After incubation of reticulocytes with radioactive amino acid, the specific activity of the beta-chain of globin from the blood of patients with thalassemia was consistently lower than that of the alpha-chain. In subjects without this disorder, the specific activity of the beta-chain was always equal to or higher than that of the alpha-chain.