A predictive model for endometrial cancer recurrence based on molecular markers and clinicopathologic parameters: A double-center retrospective study.

Objective: The purpose of this study was to establish a predictive model for endometrial cancer (EC) recurrence based on commonly used molecular markers and clinicopathologic parameters.

Methods: This was a double-center retrospective study. The data of patients were retrospectively collected from two tertiary hospitals in Chongqing, China.

Physical activity and sleep quality among pregnant women during the first and second trimesters are associated with mental health and adverse pregnancy outcomes.

Background: Appropriate physical activity (PA) and good sleep are beneficial to maternal and fetal health. This paper sought to explore the associations of PA and sleep quality among healthy women at the first and second trimesters of pregnancy on mental health and pregnancy outcomes.

Methods: Totally 268 healthy pregnant women were retrospectively analyzed as study subjects, 134 each in the first trimester (FT) and second trimester (ST).

Estradiol enhances T-type calcium channel activation in human myometrium telocytes.

Uterine peristalsis is essential for gamete transport and embryo implantation. It shares the characteristics of spontaneity, rhythmicity, and directivity with gastrointestinal peristalsis. Telocytes, the "interstitial Cajal-like cells" outside the digestive canal, are also located in the uterus and may act as pacemakers.

Determination, Isolation, and Identification of Related Impurities in Erdosteine Bulk Drug.

Background: Erdosteine is a mucolytic drug and has antioxidant activity.

Objective: The study aimed to develop an HPLC method for determination of erdosteine and its impurities in erdosteine bulk drug and to identify the main impurities to help improve the quality of erdosteine bulk drug.

Method: The chromatographic separations were performed on a CAPCELL PAK C18 column (250 mm × 4.

Identification and quantification of five impurities in cloperastine hydrochloride.

Cloperastine hydrochloride, a piperidine derivative, is a drug substance with a central antitussive effect and widely used in cough treatment; and its impurities have not been reported. Herein we isolated and identified five impurities (named as impurity A, B, C, D and E) in cloperastine hydrochloride bulk drug and developed a quantitative HPLC method. First, impurity A, B, C were enriched by ODS column chromatography and isolated by semi-preparative HPLC, at the same time, impurity D was purified by ODS column chromatography.

A risk model to predict severe postpartum hemorrhage in patients with placenta previa: a single-center retrospective study.

Background: The study aimed to establish a predictive risk model for severe postpartum hemorrhage in placenta previa using clinical and placental ultrasound imaging performed prior to delivery.

Methods: Postpartum hemorrhage patients were retrospectively enrolled. Severe postpartum hemorrhage was defined as exceeding 1,500 mL.

Soil respiration and carbon loss relationship with temperature and land use conversion in freeze-thaw agricultural area.

Soil respiration (Rs) was hypothesized to have a special response pattern to soil temperature and land use conversion in the freeze-thaw area. The Rs differences of eight types of land use conversions during agricultural development were observed and the impacts of Rs on soil organic carbon (SOC) loss were assessed. The land use conversions during last three decades were categorized into eight types, and the 141 SOC sampling sites were grouped by conversion type.

[Pharmacokinetics of S-1 capsule in patients with advanced gastric cancer].

The study is to investigate the pharmacokinetics of S-1 capsule (tegafur, gimeracil and potassium oxonate capsule) in patients with advanced gastric cancer after single and multiple oral administration. Twelve patients with advanced gastric cancer were recruited to the study. The dose of S-1 for each patient was determined according to his/her body surface area (BSA).

Comparison of three derivatization reagents for the simultaneous determination of highly hydrophilic pyrimidine antitumor agents in human plasma by LC-MS/MS.

A comparison of three derivatization reagents (dansyl chloride, diazomethane and p-bromophenacyl bromide) for the simultaneous quantitation of three anticancer chemicals (tegafur, 5-fluorouracil and gimeracil) and endogenous uracil in plasma using high performance liquid chromatography-tandem mass spectrometry (LC-MS/MS) has been developed and evaluated. Through a comprehensive consideration, p-bromophenacyl bromide (p-BPB) was finally selected as the derivatization reagent. Because it essentially changed the chromatographic behavior of the aforementioned highly hydrophilic compounds and significantly enhanced their sensitivities.